PDB entry 2wub

View 2wub on RCSB PDB site
Description: Crystal structure of HGFA in complex with the allosteric non- inhibitory antibody Fab40.deltaTrp
Class: hydrolase/immune system
Keywords: HYDROLASE IMMUNE SYSTEM COMPLEX, DISULFIDE BOND, SERINE PROTEASE, EGF-LIKE DOMAIN, ALLOSTERIC INHIBITOR, KRINGLE, ZYMOGEN, PROTEASE, SECRETED, ANTIBODY, HYDROLASE, FAB COMPLEX, GLYCOPROTEIN, HYDROLASE-IMMUNE SYSTEM complex
Deposited on 2009-10-01, released 2009-12-15
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-03-28, with a file datestamp of 2012-03-23.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: 0.216
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Hepatocyte growth factor activator long chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q04756 (0-End)
  • PDB 2WUB
• Chain 'B':
  Compound: Hepatocyte growth factor activator short chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q04756
• Chain 'C':
  Compound: Hepatocyte growth factor activator long chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q04756 (0-End)
  • PDB 2WUB
• Chain 'D':
  Compound: Hepatocyte growth factor activator short chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q04756
• Chain 'H':
  Compound: fab fragment fab40.deltatrp heavy chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • PDB 2WUB (0-End)
• Chain 'L':
  Compound: fab fragment fab40.deltatrp light chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • PDB 2WUB (0-213)
  Domains in SCOPe 2.03: d2wubl1, d2wubl2
• Chain 'Q':
  Compound: fab fragment fab40.deltatrp light chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • PDB 2WUB (0-213)
  Domains in SCOPe 2.03: d2wubq1, d2wubq2
• Chain 'R':
  Compound: fab fragment fab40.deltatrp heavy chain
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • PDB 2WUB (0-End)
• Heterogens: HOH

PDB Chain Sequences:

• Chain 'A':
  No sequence available.
  
  
• Chain 'B':
  No sequence available.
  
  
• Chain 'C':
  No sequence available.
  
  
• Chain 'D':
  No sequence available.
  
  
• Chain 'H':
  No sequence available.
  
  
• Chain 'L':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2wubL (L:)
  diqmtqspsslsasvgdrvtitcrasqdvstavawyqqkpgkapklliysasflysgvps
  rfsgsgsgtdftltisslqpedfatyycqqsnrapatfgqgtkveikrtvaapsvfifpp
  sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
  lskadyekhkvyacevthqglsspvtksfnrgec
  

  
  
• Chain 'Q':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2wubQ (Q:)
  diqmtqspsslsasvgdrvtitcrasqdvstavawyqqkpgkapklliysasflysgvps
  rfsgsgsgtdftltisslqpedfatyycqqsnrapatfgqgtkveikrtvaapsvfifpp
  sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
  lskadyekhkvyacevthqglsspvtksfnrgec
  

  
  
• Chain 'R':
  No sequence available.