PDB entry 2wtv
View 2wtv on RCSB PDB site
Description: aurora-a inhibitor structure
Class: transferase
Keywords: kinase, cell cycle, transferase, phosphoprotein
Deposited on
2009-09-22, released
2010-01-26
The last revision prior to the SCOPe 2.05 freeze date was dated
2010-04-21, with a file datestamp of
2010-04-16.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.167
AEROSPACI score: 0.37
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: serine/threonine-protein kinase 6 aurora/ipl1-related kinase 1, breast tumor-amplified kinase, aurora-a, aurora-related kinase 1, hark1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2WTV
- engineered mutation (96)
- engineered mutation (98)
- engineered mutation (101)
- Uniprot O14965
Domains in SCOPe 2.05: d2wtva_ - Chain 'B':
Compound: serine/threonine-protein kinase 6 aurora/ipl1-related kinase 1, breast tumor-amplified kinase, aurora-a, aurora-related kinase 1, hark1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2WTV
- engineered mutation (96)
- engineered mutation (98)
- engineered mutation (101)
- Uniprot O14965
Domains in SCOPe 2.05: d2wtvb_ - Chain 'C':
Compound: serine/threonine-protein kinase 6 aurora/ipl1-related kinase 1, breast tumor-amplified kinase, aurora-a, aurora-related kinase 1, hark1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2WTV
- engineered mutation (96)
- engineered mutation (98)
- engineered mutation (101)
- Uniprot O14965
Domains in SCOPe 2.05: d2wtvc_ - Chain 'D':
Compound: serine/threonine-protein kinase 6 aurora/ipl1-related kinase 1, breast tumor-amplified kinase, aurora-a, aurora-related kinase 1, hark1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2WTV
- engineered mutation (96)
- engineered mutation (98)
- engineered mutation (101)
- Uniprot O14965
Domains in SCOPe 2.05: d2wtvd_ - Heterogens: ZZL, EDO, ACT, DMS, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2wtvA (A:)
gameskkrqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehql
rreveiqshlrhpnilrlygyfhdatrvylileyaprgevykelqklskfdeqrtatyit
elanalsychskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylpp
emiegrmhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegard
lisrllkhnpsqrpmlrevlehpwitansskpsncqnkesaskqs
Sequence, based on observed residues (ATOM records): (download)
>2wtvA (A:)
krqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrrevei
qshlrhpnilrlygyfhdatrvylileyaprgevykelqklskfdeqrtatyitelanal
sychskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylppemiegr
mhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrll
khnpsqrpmlrevlehpwitanssk
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2wtvB (B:)
gameskkrqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehql
rreveiqshlrhpnilrlygyfhdatrvylileyaprgevykelqklskfdeqrtatyit
elanalsychskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylpp
emiegrmhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegard
lisrllkhnpsqrpmlrevlehpwitansskpsncqnkesaskqs
Sequence, based on observed residues (ATOM records): (download)
>2wtvB (B:)
rqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiq
shlrhpnilrlygyfhdatrvylileyaprgevykelqklskfdeqrtatyitelanals
ychskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylppemiegrm
hdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllk
hnpsqrpmlrevlehpwitanssk
- Chain 'C':
Sequence, based on SEQRES records: (download)
>2wtvC (C:)
gameskkrqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehql
rreveiqshlrhpnilrlygyfhdatrvylileyaprgevykelqklskfdeqrtatyit
elanalsychskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylpp
emiegrmhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegard
lisrllkhnpsqrpmlrevlehpwitansskpsncqnkesaskqs
Sequence, based on observed residues (ATOM records): (download)
>2wtvC (C:)
rqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreveiq
shlrhpnilrlygyfhdatrvylileyaprgevykelqklskfdeqrtatyitelanals
ychskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylppemiegrm
hdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrllk
hnpsqrpmlrevlehpwitanssk
- Chain 'D':
Sequence, based on SEQRES records: (download)
>2wtvD (D:)
gameskkrqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehql
rreveiqshlrhpnilrlygyfhdatrvylileyaprgevykelqklskfdeqrtatyit
elanalsychskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylpp
emiegrmhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegard
lisrllkhnpsqrpmlrevlehpwitansskpsncqnkesaskqs
Sequence, based on observed residues (ATOM records): (download)
>2wtvD (D:)
krqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrrevei
qshlrhpnilrlygyfhdatrvylileyaprgevykelqklskfdeqrtatyitelanal
sychskrvihrdikpenlllgsagelkiadfgwsvhapssrrttlcgtldylppemiegr
mhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrll
khnpsqrpmlrevlehpwitanssk