PDB entry 2wti

View 2wti on RCSB PDB site
Description: crystal structure of chk2 in complex with an inhibitor
Class: transferase
Keywords: transferase, kinase, cell cycle, li-fraumeni syndrome
Deposited on 2009-09-16, released 2009-12-29
The last revision prior to the SCOPe 2.07 freeze date was dated 2010-02-16, with a file datestamp of 2010-02-12.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.1974
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: checkpoint kinase 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WTI (Start-18)
    • Uniprot Q9HBS5 (19-End)
    Domains in SCOPe 2.07: d2wtia_
  • Heterogens: WTI, NO3, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wtiA (A:)
gplgshmsvypkalrdeyimsktlgsgacgevklaferktckkvaikiiskrkfaigsar
eadpalnveteieilkklnhpciikiknffdaedyyivlelmeggelfdkvvgnkrlkea
tcklyfyqmllavqylhengiihrdlkpenvllssqeedclikitdfghskilgetslmr
tlcgtptylapevlvsvgtagynravdcwslgvilficlsgyppfsehrtqvslkdqits
gkynfipevwaevsekaldlvkkllvvdpkarftteealrhpwlqdedmkrkfqdllsee
nestalpqvlaqpstsrkrpregeaegae

    Sequence, based on observed residues (ATOM records): (download) 
    >2wtiA (A:)
svypkalrdeyimsktlgsevklaferktckkvaikiiskpalnveteieilkklnhpci
ikiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfyqmllavqylhengiih
rdlkpenvllssqeedclikitdfghskiletslmrtlcgtptylapevlvsvgtagynr
avdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfipevwaevsekaldlvkkl
lvvdpkarftteealrhpwlqdedmkrkfqdllseenestalpqvl