PDB entry 2wqo

View 2wqo on RCSB PDB site
Description: structure of nek2 bound to the aminopyridine cct241950
Class: transferase
Keywords: kinase, nucleus, meiosis, mitosis, cytoplasm, alternative splicing, serine/threonine-protein kinase, metal-binding, phosphoprotein, nucleotide-binding, magnesium, cell cycle, ATP-binding, transferase, coiled coil, polymorphism, cell division
Deposited on 2009-08-24, released 2009-12-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-12-08, with a file datestamp of 2009-12-04.
Experiment type: XRAY
Resolution: 2.17 Å
R-factor: 0.186
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase nek2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P51955 (Start-270)
    • PDB 2WQO (271-278)
    Domains in SCOPe 2.08: d2wqoa1, d2wqoa2
  • Heterogens: VGK, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wqoA (A:)
mpsraedyevlytigtgsygrcqkirrksdgkilvwkeldygsmteaekqmlvsevnllr
elkhpnivryydriidrtnttlyivmeyceggdlasvitkgtkerqyldeefvlrvmtql
tlalkechrrsdgghtvlhrdlkpanvfldgkqnvklgdfglarilnhdtsfaktfvgtp
yymspeqmnrmsyneksdiwslgcllyelcalmppftafsqkelagkiregkfrripyry
sdelneiitrmlnlkdyhrpsveeilenplilehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2wqoA (A:)
sraedyevlytigtgrcqkirrksdgkilvwkeldygsmteaekqmlvsevnllrelkhp
nivryydriidrtnttlyivmeyceggdlasvitkgtkerqyldeefvlrvmtqltlalk
echrrlkpanvfldgkqnvklgdgtpyymspeqmnrneksdiwslgcllyelcalmppft
afsqkelagkiregkfrripyrysdelneiitrmlnlkdyhrpsveeilenplilehhhh
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