PDB entry 2wqb
View 2wqb on RCSB PDB site
Description: Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor
Class: transferase
Keywords: phosphoprotein, kinase, receptor, oncology, ATP-binding, transferase, glycoprotein, tyrosine-protein kinase, phosphotransferase, nucleotide-binding, disease mutation, thiazolopyrimidine
Deposited on
2009-08-18, released
2009-11-03
The last revision prior to the SCOPe 2.05 freeze date was dated
2013-04-17, with a file datestamp of
2013-04-12.
Experiment type: XRAY
Resolution: 2.95 Å
R-factor: 0.19873
AEROSPACI score: 0.25
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Angiopoietin-1 receptor
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2WQB
- engineered mutation (163)
- Uniprot Q02763
Domains in SCOPe 2.05: d2wqba_ - Heterogens: QQ1, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2wqbA (A:)
galnrkvknnpdptiypvldwndikfqdvigegnfgqvlkarikkdglrmdaaikrmkey
askddhrdfagelevlcklghhpniinllgacehrgylylaieyaphgnlldflrksrvl
etdpafaianstastlssqqllhfaadvargmdylsqkqfihrnlaarnilvgenyvaki
adfglsrgqevyvkktmgrlpvrwmaieslnysvyttnsdvwsygvllweivslggtpyc
gmtcaelyeklpqgyrlekplncddevydlmrqcwrekpyerpsfaqilvslnrmleerk
tyvnttlyekftyagidcsaeeaa
Sequence, based on observed residues (ATOM records): (download)
>2wqbA (A:)
ypvldwndikfqdvigeggqvlkarikkdglrmdaaikrmkelevlcklghhpniinllg
acehrgylylaieyaphgnlldflrksrvletdpafaianstastlssqqllhfaadvar
gmdylsqkqfihrnlaarnilvgenyvakiadfglsrgqevyvkktgrlpvrwmaiesln
ysvyttnsdvwsygvllweivslggtpycgmtcaelyeklpqgyrlekplncddevydlm
rqcwrekpyerpsfaqilvslnrmleerktyvnttlyekftyagidcsa