PDB entry 2wph
View 2wph on RCSB PDB site
Description: factor ixa superactive triple mutant
Class: blood clotting
Keywords: serine protease, zymogen, hydrolase, glycoprotein, hydroxylation, phosphoprotein, sulfation, hemostasis, hemophilia, xase-like variant, communication channel, gamma-carboxyglutamic acid, egf-like domain, disease mutation, blood clotting
Deposited on
2009-08-06, released
2009-12-22
The last revision prior to the SCOPe 2.02 freeze date was dated
2011-05-11, with a file datestamp of
2011-05-06.
Experiment type: XRAY
Resolution: 1.5 Å
R-factor: 0.24
AEROSPACI score: 0.57
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'E':
Compound: Coagulation factor IXa light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.02: d2wphe_ - Chain 'L':
Compound: d-phe-pro-arg-chloromethyl ketone
Database cross-references and differences (RAF-indexed):
- Chain 'S':
Compound: Coagulation factor IXa heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P00740 (0-234)
- engineered mutation (78)
- engineered mutation (82)
- engineered mutation (164)
Domains in SCOPe 2.02: d2wphs_ - Heterogens: CA, 1PE, HOH
PDB Chain Sequences:
- Chain 'E':
Sequence; same for both SEQRES and ATOM records: (download)
>2wphE (E:)
tcnikngrceqfcknsadnkvvcsctegyrlaenqkscepavpfpcgrvsvsqtskltr
- Chain 'L':
No sequence available.
- Chain 'S':
Sequence; same for both SEQRES and ATOM records: (download)
>2wphS (S:)
vvggedakpgqfpwqvvlngkvdafcggsivnekwivtaahcvetgvkitvvagehniee
tehteqkrnviriiphhnfnaaintynhdialleldeplvlnsyvtpiciadkeytnifl
kfgsgyvsgwgrvfhkgrsalvlqylrvplvdratclrstkftitnnmfcagfheggrds
cqgdsggphvtevegtsfltgiiswgeecamkgkygiytkvsryvnwikektklt