PDB entry 2wou

View 2wou on RCSB PDB site
Description: ALK5 IN COMPLEX WITH 4-((4-((2,6-dimethyl-3-pyridyl)oxy)-2-pyridyl) amino)benzenesulfonamide
Class: transferase
Keywords: transferase, serine/threonine-protein kinase, alk, ATP-binding, kinase inhibitor, nucleotide-binding, tgf beta type I receptor
Deposited on 2009-07-28, released 2009-09-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: TGF-beta receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WOU (0-1)
    • Uniprot P36897 (2-End)
    Domains in SCOPe 2.08: d2woua1, d2woua2
  • Heterogens: EDO, ZZF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wouA (A:)
ggtiartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhe
nilgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlh
meivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtkr
ymapevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdps
veemrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqlsq
qegikm

    Sequence, based on observed residues (ATOM records): (download) 
    >2wouA (A:)
ggtiartivlqesigkgrfgevwrgkwrgeevavkifssreerswfreaeiyqtvmlrhe
nilgfiaadnkdngtwtqlwlvsdyhehgslfdylnrytvtvegmiklalstasglahlh
meivgtqgkpaiahrdlksknilvkkngtcciadlglavrhdsatdtidiapnhrvgtkr
ymapevlddsinmkhfesfkradiyamglvfweiarrcsiggihedyqlpyydlvpsdps
veemrkvvceqklrpnipnrwqscealrvmakimrecwyangaarltalrikktlsqls