PDB entry 2wo8

View 2wo8 on RCSB PDB site
Description: mmp12 complex with a beta hydroxy carboxylic acid
Class: hydrolase
Keywords: hydrolase, polymorphism, glycoprotein, metal-binding, matrix metalloprotease mmp-12 complex structure, metalloprotease, extracellular matrix, zymogen, protease, secreted
Deposited on 2009-07-22, released 2009-09-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-09-22, with a file datestamp of 2009-09-18.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.18728
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Macrophage metalloelastase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WO8 (0-0)
    • Uniprot P39900 (1-163)
    Domains in SCOPe 2.08: d2wo8a1, d2wo8a2
  • Chain 'B':
    Compound: Macrophage metalloelastase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WO8 (0-0)
    • Uniprot P39900 (1-End)
    Domains in SCOPe 2.08: d2wo8b_
  • Chain 'C':
    Compound: Macrophage metalloelastase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WO8 (0-0)
    • Uniprot P39900 (1-End)
    Domains in SCOPe 2.08: d2wo8c_
  • Chain 'D':
    Compound: Macrophage metalloelastase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WO8
    • Uniprot P39900 (1-End)
    Domains in SCOPe 2.08: d2wo8d_
  • Heterogens: ZN, CA, 077, SO4, 023, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2wo8A (A:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslygdpken

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2wo8B (B:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslygdpken

    Sequence, based on observed residues (ATOM records): (download) 
    >2wo8B (B:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslygdpke

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2wo8C (C:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslygdpken

    Sequence, based on observed residues (ATOM records): (download) 
    >2wo8C (C:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslygdpke

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2wo8D (D:)
mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
rgahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighsl
glghssdpkavmfptykyvdintfrlsaddirgiqslygdpken

    Sequence, based on observed residues (ATOM records): (download) 
    >2wo8D (D:)
gpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfar
gahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavheighslg
lghssdpkavmfptykyvdintfrlsaddirgiqslygdp