PDB entry 2wns

View 2wns on RCSB PDB site
Description: human orotate phosphoribosyltransferase (oprtase) domain of uridine 5'-monophosphate synthase (umps) in complex with its substrate orotidine 5'-monophosphate (omp)
Class: transferase
Keywords: alternative splicing, multifunctional enzyme, lyase, transferase, polymorphism, decarboxylase, phosphoprotein, disease mutation, glycosyltransferase, pyrimidine biosynthesis
Deposited on 2009-07-19, released 2009-08-11
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-08-11, with a file datestamp of 2009-08-07.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.18244
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: orotate phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WNS
    • Uniprot P11172 (1-197)
    Domains in SCOPe 2.06: d2wnsa_
  • Chain 'B':
    Compound: orotate phosphoribosyltransferase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WNS (198-End)
    • Uniprot P11172 (Start-197)
    Domains in SCOPe 2.06: d2wnsb1, d2wnsb2
  • Heterogens: OMP, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wnsA (A:)
malgplvtglydvqafkfgdfvlksglsspiyidlrgivsrprllsqvadilfqtaqnag
isfdtvcgvpytalplatvicstnqipmlirrketkdygtkrlvegtinpgetcliiedv
vtsgssvletvevlqkeglkvtdaivlldreqggkdklqahgirlhsvctlskmleileq
qkkvdaetvgrvkrfiqeahhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2wnsA (A:)
algplvtglydvqafkfgdfvlksglsspiyidlrgivsrprllsqvadilfqtaqnagi
sfdtvcgvpytalplatvicstnqipmlirrketkdygtkrlvegtinpgetcliiedvv
tsgssvletvevlqkeglkvtdaivlldreqggkdklqahgirlhsvctlskmleileqq
kkvdaetvgrvkrfiqe

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2wnsB (B:)
malgplvtglydvqafkfgdfvlksglsspiyidlrgivsrprllsqvadilfqtaqnag
isfdtvcgvpytalplatvicstnqipmlirrketkdygtkrlvegtinpgetcliiedv
vtsgssvletvevlqkeglkvtdaivlldreqggkdklqahgirlhsvctlskmleileq
qkkvdaetvgrvkrfiqeahhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2wnsB (B:)
lgplvtglydvqafkfgdfvlksglsspiyidlrgivsrprllsqvadilfqtaqnagis
fdtvcgvpytalplatvicstnqipmlirrketkdygtkrlvegtinpgetcliiedvvt
sgssvletvevlqkeglkvtdaivlldreqggkdklqahgirlhsvctlskmleileqqk
kvdaetvgrvkrfiqeahh