PDB entry 2wmx

View 2wmx on RCSB PDB site
Description: Crystal structure of checkpoint kinase 1 (Chk1) in complex with inhibitors
Class: transferase
Keywords: serine/threonine-protein kinase, polymorphism, phosphoprotein, ubl conjugation, isopeptide bond, checkpoint kinase, nucleotide-binding, serine/threonine kinase, DNA damage, DNA repair, ATP-binding, transferase, chk1, kinase, nucleus, cytoplasm, cell cycle
Deposited on 2009-07-03, released 2009-07-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-06-28, with a file datestamp of 2017-06-23.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase Chk1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2wmxa_
  • Heterogens: ZY6, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wmxA (A:)
mavpfvedwdlvqtlgegaygevqlavnrvteeavavkivdmkravdcpenikkeicink
mlnhenvvkfyghrregniqylfleycsggelfdriepdigmpepdaqrffhqlmagvvy
lhgigithrdikpenlllderdnlkisdfglatvfrynnrerllnkmcgtlpyvapellk
rrefhaepvdvwscgivltamlagelpwdqpsdscqeysdwkekktylnpwkkidsapla
llhkilvenpsaritipdikkdrwynkplkkgakrprvtsggvsespsg

    Sequence, based on observed residues (ATOM records): (download) 
    >2wmxA (A:)
edwdlvqtlgevqlavnrvteeavavkivdmnikkeicinkmlnhenvvkfyghrreiqy
lfleycsggelfdriepdigmpepdaqrffhqlmagvvylhgigithrdikpenlllder
dnlkisdfglatvfrynnrerllnkmcgtlpyvapellkrrefhaepvdvwscgivltam
lagelpwdqpsdscqeysdwkekktylnpwkkidsaplallhkilvenpsaritipdikk
drwynkpl