PDB entry 2wkz

View 2wkz on RCSB PDB site
Description: HIV-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-State Mimic with Improved Cell-Based Antiviral Activity
Class: hydrolase
Keywords: transition-state mimic, inhibitor, hydrolase
Deposited on 2009-06-19, released 2009-12-15
The last revision prior to the SCOPe 2.05 freeze date was dated 2014-03-12, with a file datestamp of 2014-03-07.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.2288
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Protease
  Species: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (Z2/CDC-Z34 ISOLATE) [TaxId:11683]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03366
  Domains in SCOPe 2.05: d2wkza_
• Chain 'B':
  Compound: Protease
  Species: HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (Z2/CDC-Z34 ISOLATE) [TaxId:11683]
  Database cross-references and differences (RAF-indexed):
  • Uniprot P03366 (0-98)
  Domains in SCOPe 2.05: d2wkzb_
• Heterogens: 5AH, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2wkzA (A:)
  pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
  qilieicghkaigtvlvgptpvniigrnlltqigctlnf
  

  
  
• Chain 'B':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >2wkzB (B:)
  pqitlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
  qilieicghkaigtvlvgptpvniigrnlltqigctlnf