PDB entry 2wk6

View 2wk6 on RCSB PDB site
Description: structural features of native human thymidine phosphorylase and in complex with 5-iodouracil
Class: transferase
Keywords: glycosyltransferase, developmental protein, angiogenesis, 5-iodouracil, growth factor, enzyme kinetics, differentiation, disease mutation, thymidine phosphorylase, chemotaxis, transferase, mutagenesis, polymorphism
Deposited on 2009-06-05, released 2009-07-07
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-07-28, with a file datestamp of 2009-07-24.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.227
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: thymidine phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2wk6a1, d2wk6a2, d2wk6a3
  • Chain 'B':
    Compound: thymidine phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d2wk6b1, d2wk6b2, d2wk6b3
  • Heterogens: IUR, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wk6A (A:)
maalmtpgtgappapgdfsgegsqglpdpspepkqlpelirmkrdggrlseadirgfvaa
vvngsaqgaqigamlmairlrgmdleetsvltqalaqsgqqlewpeawrqqlvdkhstgg
vgdkvslvlapalaacgckvpmisgrglghtggtldklesipgfnviqspeqmqvlldqa
gccivgqseqlvpadgilyaardvtatvdslplitasilskklveglsalvvdvkfggaa
vfpnqeqarelaktlvgvgaslglrvaaaltamdkplgrcvghaleveeallcmdgagpp
dlrdlvttlggallwlsghagtqaqgaarvaaalddgsalgrfermlaaqgvdpglaral
csgspaerrqllprareqeellapadgtvelvralplalvlhelgagrsrageplrlgvg
aellvdvgqrlrrgtpwlrvhrdgpalsgpqsralqealvlsdrapfaapspfaelvlpp
qq

    Sequence, based on observed residues (ATOM records): (download) 
    >2wk6A (A:)
qlpelirmkrdggrlseadirgfvaavvngsaqgaqigamlmairlrgmdleetsvltqa
laqsgqqlewpeawrqqlvdkhstggvgdkvslvlapalaacgckvpmisgrglghtggt
ldklesipgfnviqspeqmqvlldqagccivgqseqlvpadgilyaardvtatvdslpli
tasilskklveglsalvvdvkfggaavfpnqeqarelaktlvgvgaslglrvaaaltamd
kplgrcvghaleveeallcmdgagppdlrdlvttlggallwlsghagtqaqgaarvaaal
ddgsalgrfermlaaqgvdpglaralcsgspaerrqllprareqeellapadgtvelvra
lplalvlhelgagrsrageplrlgvgaellvdvgqrlrrgtpwlrvhrdgpalsgpqsra
lqealvlsdrapfaapspfaelvlppq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2wk6B (B:)
maalmtpgtgappapgdfsgegsqglpdpspepkqlpelirmkrdggrlseadirgfvaa
vvngsaqgaqigamlmairlrgmdleetsvltqalaqsgqqlewpeawrqqlvdkhstgg
vgdkvslvlapalaacgckvpmisgrglghtggtldklesipgfnviqspeqmqvlldqa
gccivgqseqlvpadgilyaardvtatvdslplitasilskklveglsalvvdvkfggaa
vfpnqeqarelaktlvgvgaslglrvaaaltamdkplgrcvghaleveeallcmdgagpp
dlrdlvttlggallwlsghagtqaqgaarvaaalddgsalgrfermlaaqgvdpglaral
csgspaerrqllprareqeellapadgtvelvralplalvlhelgagrsrageplrlgvg
aellvdvgqrlrrgtpwlrvhrdgpalsgpqsralqealvlsdrapfaapspfaelvlpp
qq

    Sequence, based on observed residues (ATOM records): (download) 
    >2wk6B (B:)
qlpelirmkrdggrlseadirgfvaavvngsaqgaqigamlmairlrgmdleetsvltqa
laqsgqqlewpeawrqqlvdkhstggvgdkvslvlapalaacgckvpmisgrglghtggt
ldklesipgfnviqspeqmqvlldqagccivgqseqlvpadgilyaardvtatvdslpli
tasilskklveglsalvvdvkfggaavfpnqeqarelaktlvgvgaslglrvaaaltamd
kplgrcvghaleveeallcmdgagppdlrdlvttlggallwlsghagtqaqgaarvaaal
ddgsalgrfermlaaqgvdpglaralcsgspaerrqllprareqeellapadgtvelvra
lplalvlhelgagrsrageplrlgvgaellvdvgqrlrrgtpwlrvhrdgpalsgpqsra
lqealvlsdrapfaapspfaelvlppq