PDB entry 2wk5

View 2wk5 on RCSB PDB site
Description: structural features of native human thymidine phosphorylase and in complex with 5-iodouracil
Class: transferase
Keywords: glycosyltransferase, developmental protein, angiogenesis, 5-iodouracil, growth factor, enzyme kinetics, differentiation, disease mutation, thymidine phosphorylase, chemotaxis, transferase, mutagenesis, polymorphism
Deposited on 2009-06-05, released 2009-07-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-07-28, with a file datestamp of 2009-07-24.
Experiment type: XRAY
Resolution: 2.99 Å
R-factor: 0.207
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: thymidine phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2wk5a1, d2wk5a2, d2wk5a3
  • Chain 'B':
    Compound: thymidine phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2wk5b1, d2wk5b2, d2wk5b3
  • Chain 'C':
    Compound: thymidine phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2wk5c1, d2wk5c2, d2wk5c3
  • Chain 'D':
    Compound: thymidine phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2wk5d1, d2wk5d2, d2wk5d3
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wk5A (A:)
maalmtpgtgappapgdfsgegsqglpdpspepkqlpelirmkrdggrlseadirgfvaa
vvngsaqgaqigamlmairlrgmdleetsvltqalaqsgqqlewpeawrqqlvdkhstgg
vgdkvslvlapalaacgckvpmisgrglghtggtldklesipgfnviqspeqmqvlldqa
gccivgqseqlvpadgilyaardvtatvdslplitasilskklveglsalvvdvkfggaa
vfpnqeqarelaktlvgvgaslglrvaaaltamdkplgrcvghaleveeallcmdgagpp
dlrdlvttlggallwlsghagtqaqgaarvaaalddgsalgrfermlaaqgvdpglaral
csgspaerrqllprareqeellapadgtvelvralplalvlhelgagrsrageplrlgvg
aellvdvgqrlrrgtpwlrvhrdgpalsgpqsralqealvlsdrapfaapspfaelvlpp
qq

    Sequence, based on observed residues (ATOM records): (download) 
    >2wk5A (A:)
epkqlpelirmkrdggrlseadirgfvaavvngsaqgaqigamlmairlrgmdleetsvl
tqalaqsgqqlewpeawrqqlvdkhstggvgdkvslvlapalaacgckvpmisgrglght
ggtldklesipgfnviqspeqmqvlldqagccivgqseqlvpadgilyaardvtatvdsl
plitasilskklveglsalvvdvkfggaavfpnqeqarelaktlvgvgaslglrvaaalt
amdkplgrcvghaleveeallcmdgagppdlrdlvttlggallwlsghagtqaqgaarva
aalddgsalgrfermlaaqgvdpglaralcsgspaerrqllprareqeellapadgtvel
vralplalvlhelgagrsrageplrlgvgaellvdvgqrlrrgtpwlrvhrdgpalsgpq
sralqealvlsdrapfaapspfaelvlpp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2wk5B (B:)
maalmtpgtgappapgdfsgegsqglpdpspepkqlpelirmkrdggrlseadirgfvaa
vvngsaqgaqigamlmairlrgmdleetsvltqalaqsgqqlewpeawrqqlvdkhstgg
vgdkvslvlapalaacgckvpmisgrglghtggtldklesipgfnviqspeqmqvlldqa
gccivgqseqlvpadgilyaardvtatvdslplitasilskklveglsalvvdvkfggaa
vfpnqeqarelaktlvgvgaslglrvaaaltamdkplgrcvghaleveeallcmdgagpp
dlrdlvttlggallwlsghagtqaqgaarvaaalddgsalgrfermlaaqgvdpglaral
csgspaerrqllprareqeellapadgtvelvralplalvlhelgagrsrageplrlgvg
aellvdvgqrlrrgtpwlrvhrdgpalsgpqsralqealvlsdrapfaapspfaelvlpp
qq

    Sequence, based on observed residues (ATOM records): (download) 
    >2wk5B (B:)
epkqlpelirmkrdggrlseadirgfvaavvngsaqgaqigamlmairlrgmdleetsvl
tqalaqsgqqlewpwrqqlvdkhstggvgdkvslvlapalaacgckvpmisgrglghtgg
tldklesipgfnviqspeqmqvlldqagccivgqseqlvpadgilyaardvtatvdslpl
itasilskklveglsalvvdvkfggaavfpnqeqarelaktlvgvgaslglrvaaaltam
dkplgrcvghaleveeallcmdgagppdlrdlvttlggallwlsghagtqaqgaarvaaa
lddgsalgrfermlaaqgvdpglaralcsgspaerrqllprareqeellapadgtvelvr
alplalvlhelgagrsrageplrlgvgaellvdvgqrlrrgtpwlrvhrdgpalsgpqsr
alqealvlsdrapfaapspfaelvlppq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2wk5C (C:)
maalmtpgtgappapgdfsgegsqglpdpspepkqlpelirmkrdggrlseadirgfvaa
vvngsaqgaqigamlmairlrgmdleetsvltqalaqsgqqlewpeawrqqlvdkhstgg
vgdkvslvlapalaacgckvpmisgrglghtggtldklesipgfnviqspeqmqvlldqa
gccivgqseqlvpadgilyaardvtatvdslplitasilskklveglsalvvdvkfggaa
vfpnqeqarelaktlvgvgaslglrvaaaltamdkplgrcvghaleveeallcmdgagpp
dlrdlvttlggallwlsghagtqaqgaarvaaalddgsalgrfermlaaqgvdpglaral
csgspaerrqllprareqeellapadgtvelvralplalvlhelgagrsrageplrlgvg
aellvdvgqrlrrgtpwlrvhrdgpalsgpqsralqealvlsdrapfaapspfaelvlpp
qq

    Sequence, based on observed residues (ATOM records): (download) 
    >2wk5C (C:)
pkqlpelirmkrdggrlseadirgfvaavvngsaqgaqigamlmairlrgmdleetsvlt
qalaqsgqqlewpeawrqqlvdkhstggvgdkvslvlapalaacgckvpmisgrglghtg
gtldklesipgfnviqspeqmqvlldqagccivgqseqlvpadgilyaardvtatvdslp
litasilskklveglsalvvdvkfggaavfpnqeqarelaktlvgvgaslglrvaaalta
mdkplgrcvghaleveeallcmdgagppdlrdlvttlggallwlsghagtqaqgaarvaa
alddgsalgrfermlaaqgvdpglaralcsgspaerrqllprareqeellapadgtvelv
ralplalvlhelgagrsrageplrlgvgaellvdvgqrlrrgtpwlrvhrdgpalsgpqs
ralqealvlsdraapspfaelvlpp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2wk5D (D:)
maalmtpgtgappapgdfsgegsqglpdpspepkqlpelirmkrdggrlseadirgfvaa
vvngsaqgaqigamlmairlrgmdleetsvltqalaqsgqqlewpeawrqqlvdkhstgg
vgdkvslvlapalaacgckvpmisgrglghtggtldklesipgfnviqspeqmqvlldqa
gccivgqseqlvpadgilyaardvtatvdslplitasilskklveglsalvvdvkfggaa
vfpnqeqarelaktlvgvgaslglrvaaaltamdkplgrcvghaleveeallcmdgagpp
dlrdlvttlggallwlsghagtqaqgaarvaaalddgsalgrfermlaaqgvdpglaral
csgspaerrqllprareqeellapadgtvelvralplalvlhelgagrsrageplrlgvg
aellvdvgqrlrrgtpwlrvhrdgpalsgpqsralqealvlsdrapfaapspfaelvlpp
qq

    Sequence, based on observed residues (ATOM records): (download) 
    >2wk5D (D:)
kqlpelirmkrdggrlseadirgfvaavvngsaqgaqigamlmairlrgmdleetsvltq
alaqsgqqewpeawrqqlvdkhstggvgdkvslvlapalaacgckvpmisgrglghtggt
ldklesipgfnviqspeqmqvlldqagccivgqseqlvpadgilyaardvtatvdslpli
tasilskklveglsalvvdvkfggaavfpnqeqarelaktlvgvgaslglrvaaaltamd
kplgrcvghaleveeallcmdgagppdlrdlvttlggallwlsghagtqaqgaarvaaal
ddgsalgrfermlaaqgvdpglaralcgspaerrqllprareqeellapadgtvelvral
plalvlhelgagrsrageplrlgvgaellvdvgqrlrrgtpwlrvhrdgpalsgpqsral
qealvlsdrapfaapspfaelvlpp