PDB entry 2wk3

View 2wk3 on RCSB PDB site
Description: crystal structure of human insulin-degrading enzyme in complex with amyloid-beta (1-42)
Deposited on 2009-06-05, released 2009-11-03
The last revision was dated 2010-02-09, with a file datestamp of 2010-02-05.
Experiment type: XRAY
Resolution: 2.59 Å
R-factor: 0.189
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: insulin degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735
      • engineered mutation (109-110)
      • engineered mutation (170)
      • engineered mutation (177)
      • engineered mutation (256)
      • engineered mutation (413)
      • engineered mutation (572)
      • engineered mutation (589)
      • engineered mutation (788)
      • engineered mutation (811)
      • engineered mutation (818)
      • engineered mutation (903)
      • engineered mutation (965)
  • Chain 'B':
    Compound: insulin degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14735
      • engineered mutation (109-110)
      • engineered mutation (170)
      • engineered mutation (177)
      • engineered mutation (256)
      • engineered mutation (413)
      • engineered mutation (572)
      • engineered mutation (589)
      • engineered mutation (788)
      • engineered mutation (811)
      • engineered mutation (818)
      • engineered mutation (903)
  • Chain 'C':
    Compound: beta-amyloid protein 42
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: beta-amyloid protein 42
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: ZN, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2wk3A (A:)
    mryrlawllhpalpstfrsvlgarlppperlcgfqkktyskmnnpaikrignhitksped
    kreyrglelangikvllisdpttdkssaaldvhigslsdppniaglshflqhmlflgtkk
    ypkeneysqflsehagssnaftsgehtnyyfdvshehlegaldrfaqfflsplfdesakd
    revnavdseheknvmndawrlfqlekatgnpkhpfskfgtgnkytletrpnqegidvrqe
    llkfhsayyssnlmavvvlgreslddltnlvvklfsevenknvplpefpehpfqeehlkq
    lykivpikdirnlyvtfpipdlqkyyksnpghylghlighegpgsllselkskgwvntlv
    ggqkegargfmffiinvdlteegllhvediilhmfqyiqklraegpqewvfqelkdlnav
    afrfkdkerprgytskiagilhyypleevltaeylleefrpdliemvldklrpenvrvai
    vsksfegktdrteewygtqykqeaipdevikkwqnadlngkfklptknefiptnfeilpl
    ekeatpypalikdtamsklwfkqddkfflpkanlnfeffspfayvdplhsnmaylylell
    kdslneyayaaelaglsydlqntiygmylsvkgyndkqpillkkiiekmatfeidekrfe
    iikeaymrslnnfraeqphqhamyylrllmtevawtkdelkealddvtlprlkafipqll
    srlhieallhgnitkqaalgimqmvedtliehahtkpllpsqlvryrevqlpdrgwfvyq
    qrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafntlrtkeqlgyivfsgprra
    ngiqglrfiiqsekpphylesrveaflitmeksiedmteeafqkhiqalairrldkpkkl
    saesakywgeiisqqynfdrdntevaylktltkediikfykemlavdaprrhkvsvhvla
    remdsnpvvgefpaqndinlsqapalpqpeviqnmtefkrglplfplvkphinfmaakl
    

    Sequence, based on observed residues (ATOM records):
    >2wk3A (A:)
    nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
    iaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
    drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
    kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
    vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
    pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
    aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
    liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
    klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
    ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
    kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
    alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
    lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
    lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
    qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
    mlavdaprrhkvsvhvlaremdsnnlsqapalpqpeviqnmtefkrglplfplvkphi
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2wk3B (B:)
    mryrlawllhpalpstfrsvlgarlppperlcgfqkktyskmnnpaikrignhitksped
    kreyrglelangikvllisdpttdkssaaldvhigslsdppniaglshflqhmlflgtkk
    ypkeneysqflsehagssnaftsgehtnyyfdvshehlegaldrfaqfflsplfdesakd
    revnavdseheknvmndawrlfqlekatgnpkhpfskfgtgnkytletrpnqegidvrqe
    llkfhsayyssnlmavvvlgreslddltnlvvklfsevenknvplpefpehpfqeehlkq
    lykivpikdirnlyvtfpipdlqkyyksnpghylghlighegpgsllselkskgwvntlv
    ggqkegargfmffiinvdlteegllhvediilhmfqyiqklraegpqewvfqelkdlnav
    afrfkdkerprgytskiagilhyypleevltaeylleefrpdliemvldklrpenvrvai
    vsksfegktdrteewygtqykqeaipdevikkwqnadlngkfklptknefiptnfeilpl
    ekeatpypalikdtamsklwfkqddkfflpkanlnfeffspfayvdplhsnmaylylell
    kdslneyayaaelaglsydlqntiygmylsvkgyndkqpillkkiiekmatfeidekrfe
    iikeaymrslnnfraeqphqhamyylrllmtevawtkdelkealddvtlprlkafipqll
    srlhieallhgnitkqaalgimqmvedtliehahtkpllpsqlvryrevqlpdrgwfvyq
    qrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafntlrtkeqlgyivfsgprra
    ngiqglrfiiqsekpphylesrveaflitmeksiedmteeafqkhiqalairrldkpkkl
    saesakywgeiisqqynfdrdntevaylktltkediikfykemlavdaprrhkvsvhvla
    remdsnpvvgefpaqndinlsqapalpqpeviqnmtefkrglplfplvkphinfmaakl
    

    Sequence, based on observed residues (ATOM records):
    >2wk3B (B:)
    npaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppni
    aglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegald
    rfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgnk
    ytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenknv
    plpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghlighegp
    gsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklra
    egpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpdl
    iemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkfk
    lptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspfa
    yvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpillk
    kiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelkea
    lddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsql
    vryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafntl
    rtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeafq
    khiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfykem
    lavdaprrhkvsvhvlaremdsnlsqapalpqpeviqnmtefkrglplfplvkphi
    

  • Chain 'C':
    Sequence, based on SEQRES records:
    >2wk3C (C:)
    daefrhdsgyevhhqklvffaedvgsnkgaiiglmvggvvia
    

    Sequence, based on observed residues (ATOM records):
    >2wk3C (C:)
    daeklvffae
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >2wk3D (D:)
    daefrhdsgyevhhqklvffaedvgsnkgaiiglmvggvvia
    

    Sequence, based on observed residues (ATOM records):
    >2wk3D (D:)
    daeklvffae