PDB entry 2wjz

View 2wjz on RCSB PDB site
Description: Crystal structure of (HisH) K181A Y138A mutant of imidazoleglycerolphosphate synthase (HisH HisF) which displays constitutive glutaminase activity
Class: lyase/transferase
Keywords: lyase-transferase complex, amino-acid biosynthesis, ammonia channel, histidine biosynthesis, cyclase, glutaminase
Deposited on 2009-06-02, released 2010-08-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-01-09, with a file datestamp of 2013-01-04.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.1869
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: imidazole glycerol phosphate synthase hisf
    Species: Thermotoga maritima [TaxId:2336]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2wjza_
  • Chain 'B':
    Compound: imidazole glycerol phosphate synthase subunit hish
    Species: Thermotoga maritima [TaxId:2336]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9X0C8 (0-End)
      • engineered mutation (180)
      • engineered mutation (137)
    Domains in SCOPe 2.08: d2wjzb_
  • Chain 'C':
    Compound: imidazole glycerol phosphate synthase hisf
    Species: Thermotoga maritima [TaxId:2336]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2wjzc_
  • Chain 'D':
    Compound: imidazole glycerol phosphate synthase subunit hish
    Species: Thermotoga maritima [TaxId:2336]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9X0C8 (0-End)
      • engineered mutation (180)
      • engineered mutation (137)
    Domains in SCOPe 2.08: d2wjzd_
  • Chain 'E':
    Compound: imidazole glycerol phosphate synthase hisf
    Species: Thermotoga maritima [TaxId:2336]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2wjze_
  • Chain 'F':
    Compound: imidazole glycerol phosphate synthase subunit hish
    Species: Thermotoga maritima [TaxId:2336]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9X0C8 (0-End)
      • engineered mutation (180)
      • engineered mutation (137)
    Domains in SCOPe 2.08: d2wjzf_
  • Heterogens: PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wjzA (A:)
mlakriiacldvkdgrvvkgtnfenlrdsgdpvelgkfyseigidelvflditasvekrk
tmlelvekvaeqidipftvgggihdfetaselilrgadkvsintaavenpslitqiaqtf
gsqavvvaidakrvdgefmvftysgkkntgillrdwvvevekrgageilltsidrdgtks
gydtemirfvrplttlpiiasggagkmehfleaflagadaalaasvfhfreidvrelkey
lkkhgvnvrlegl

    Sequence, based on observed residues (ATOM records): (download) 
    >2wjzA (A:)
mlakriiacldvkdgrvvkgtnfenlrdsgdpvelgkfyseigidelvflditasvekrk
tmlelvekvaeqidipftvgggihdfetaselilrgadkvsintaavenpslitqiaqtf
gsqavvvaidakrvdgefmvftysgkkntgillrdwvvevekrgageilltsidrdgtks
gydtemirfvrplttlpiiasggagkmehfleaflagadaalaasvfhfreidvrelkey
lkkhgvnvrle

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2wjzB (B:)
mrigiisvgpgnimnlyrgvkrasenfedvsielvesprndlydllfipgvghfgegmrr
lrendlidfvrkhvederyvvgvclgmqllfeeseeapgvkglsliegnvvklrsrrlph
mgwnevifkdtfpngyyafvhtyravceeehvlgtteydgeifpsavrkgrilgfqfhpe
asskigrkllekviecslsrr

    Sequence, based on observed residues (ATOM records): (download) 
    >2wjzB (B:)
mrigiisvgpgnimnlyrgvkrasenfedvsielvesprydllfipgvhfgegmrrlren
dlidfvrkhvederyvvgvclgmqllfeeseapgvkglsliegnvvklrsrrlphmgwne
vifkdtfpngyyafvhtyravceeehvlgtteydgeifpsavrkgrilgfqfhpeasski
grkllekviecsl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2wjzC (C:)
mlakriiacldvkdgrvvkgtnfenlrdsgdpvelgkfyseigidelvflditasvekrk
tmlelvekvaeqidipftvgggihdfetaselilrgadkvsintaavenpslitqiaqtf
gsqavvvaidakrvdgefmvftysgkkntgillrdwvvevekrgageilltsidrdgtks
gydtemirfvrplttlpiiasggagkmehfleaflagadaalaasvfhfreidvrelkey
lkkhgvnvrlegl

    Sequence, based on observed residues (ATOM records): (download) 
    >2wjzC (C:)
mlakriiacldvkdgrvvkgtnfenlrdsgdpvelgkfyseigidelvflditasvekrk
tmlelvekvaeqidipftvgggihdfetaselilrgadkvsintaavenpslitqiaqtf
gsqavvvaidakrvdgefmvftysgkkntgillrdwvvevekrgageilltsidrdgtks
gydtemirfvrplttlpiiasggagkmehfleaflagadaalaasvfhfreidvrelkey
lkkhgvnvrle

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2wjzD (D:)
mrigiisvgpgnimnlyrgvkrasenfedvsielvesprndlydllfipgvghfgegmrr
lrendlidfvrkhvederyvvgvclgmqllfeeseeapgvkglsliegnvvklrsrrlph
mgwnevifkdtfpngyyafvhtyravceeehvlgtteydgeifpsavrkgrilgfqfhpe
asskigrkllekviecslsrr

    Sequence, based on observed residues (ATOM records): (download) 
    >2wjzD (D:)
mrigiisvgpgnimnlyrgvkrasenfedvsielvesprlydllfipgvghfgegmrrlr
endlidfvrkhvederyvvgvclgmqllfeeseeapgvkglsliegnvvklrsrrlphmg
wnevifkdtfpngyyafvhtyravceeehvlgtteydgeifpsavrkgrilgfqfhpeas
skigrkllekviecsl

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2wjzE (E:)
mlakriiacldvkdgrvvkgtnfenlrdsgdpvelgkfyseigidelvflditasvekrk
tmlelvekvaeqidipftvgggihdfetaselilrgadkvsintaavenpslitqiaqtf
gsqavvvaidakrvdgefmvftysgkkntgillrdwvvevekrgageilltsidrdgtks
gydtemirfvrplttlpiiasggagkmehfleaflagadaalaasvfhfreidvrelkey
lkkhgvnvrlegl

    Sequence, based on observed residues (ATOM records): (download) 
    >2wjzE (E:)
mlakriiacldvkdgrvvgdpvelgkfyseigidelvflditakrktmlelvekvaeqid
ipftvgggihdfetaselilrgadkvsintaavenpslitqiaqtfgsqavvvaidakrv
dgefmvftysgkkntgillrdwvvevekrgageilltsidrdgtksgydtemirfvrplt
tlpiiasggagkmehfleaflagadaalaasvfhfreidvrelkeylkkhgvnvrle

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2wjzF (F:)
mrigiisvgpgnimnlyrgvkrasenfedvsielvesprndlydllfipgvghfgegmrr
lrendlidfvrkhvederyvvgvclgmqllfeeseeapgvkglsliegnvvklrsrrlph
mgwnevifkdtfpngyyafvhtyravceeehvlgtteydgeifpsavrkgrilgfqfhpe
asskigrkllekviecslsrr

    Sequence, based on observed residues (ATOM records): (download) 
    >2wjzF (F:)
mrigiisvgpgnimnlyrgvkrasenfedvsielvesprlydllfipgvghfgegmrrlr
endlidfvrkhvederyvvgvclgmqllfeeseeapgvkglsliegnvvklrsrrlphmg
wnevifkdtfpngyyafvhtyravceeehvlgtteydgeifpsavrkgrilgfqfhpeas
skigrkllekviecsl