PDB entry 2wj2

View 2wj2 on RCSB PDB site
Description: 3d-crystal structure of humanized-rat fatty acid amide hydrolase (faah) conjugated with 7-phenyl-1-(5-(pyridin-2-yl)oxazol-2-yl)heptan-1-one, an alpha-ketooxazole
Class: hydrolase
Keywords: endoplasmic reticulum, monotopic membrane protein, membrane, hydrolase, transmembrane, phosphoprotein, covalent reversible inhibitors, fatty acid amide hydrolase, golgi apparatus, alpha-ketooxazole
Deposited on 2009-05-19, released 2009-09-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-09-15, with a file datestamp of 2009-09-11.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: 0.1864
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fatty acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WJ2
      • engineered mutation (185)
      • engineered mutation (187)
      • engineered mutation (370)
      • engineered mutation (428)
      • engineered mutation (484)
      • engineered mutation (488)
    • Uniprot P97612
    Domains in SCOPe 2.08: d2wj2a_
  • Chain 'B':
    Compound: fatty acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WJ2
      • engineered mutation (185)
      • engineered mutation (187)
      • engineered mutation (370)
      • engineered mutation (428)
      • engineered mutation (484)
      • engineered mutation (488)
    • Uniprot P97612
    Domains in SCOPe 2.08: d2wj2b_
  • Heterogens: OL1, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wj2A (A:)
mgsshhhhhhssglvprgshmasrwtgrqkargaatrarqkqrasletmdkavqrfrlqn
pdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqls
qaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtn
vpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfps
afcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftld
ptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpn
nipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplf
prlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgr
atgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglp
vavqcvalpwqeelclrfmreveqlmtpqkqps

    Sequence, based on observed residues (ATOM records): (download) 
    >2wj2A (A:)
grqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgels
peavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghds
tlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkssk
spggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvyg
qtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyyet
dnytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqnf
kgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqheie
myrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvttv
taeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveqlm
tpqkqp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2wj2B (B:)
mgsshhhhhhssglvprgshmasrwtgrqkargaatrarqkqrasletmdkavqrfrlqn
pdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqls
qaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtn
vpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfps
afcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftld
ptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpn
nipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplf
prlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgr
atgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglp
vavqcvalpwqeelclrfmreveqlmtpqkqps

    Sequence, based on observed residues (ATOM records): (download) 
    >2wj2B (B:)
grqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgels
peavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghds
tlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkssk
spggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvyg
qtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyyet
dnytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqnf
kgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqheie
myrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvttv
taeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveqlm
tpqkq