PDB entry 2wj1

View 2wj1 on RCSB PDB site
Description: 3d-crystal structure of humanized-rat fatty acid amide hydrolase (faah) conjugated with 7-phenyl-1-(4-(pyridin-2-yl)oxazol-2-yl)heptan-1-one, an alpha-ketooxazole
Class: hydrolase
Keywords: monotopic membrane protein, fatty acid amide hydrolase, golgi apparatus, endoplasmic reticulum, membrane, hydrolase, transmembrane, phosphoprotein, covalent reversible inhibitor
Deposited on 2009-05-19, released 2009-09-15
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-11-03, with a file datestamp of 2009-10-30.
Experiment type: XRAY
Resolution: 1.84 Å
R-factor: 0.1873
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fatty-acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WJ1
      • engineered mutation (185)
      • engineered mutation (187)
      • engineered mutation (370)
      • engineered mutation (428)
      • engineered mutation (484)
      • engineered mutation (488)
    • Uniprot P97612
    Domains in SCOPe 2.08: d2wj1a_
  • Chain 'B':
    Compound: fatty-acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WJ1
      • engineered mutation (185)
      • engineered mutation (187)
      • engineered mutation (370)
      • engineered mutation (428)
      • engineered mutation (484)
      • engineered mutation (488)
    • Uniprot P97612
    Domains in SCOPe 2.08: d2wj1b_
  • Heterogens: S99, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2wj1A (A:)
    mgsshhhhhhssglvprgshmasrwtgrqkargaatrarqkqrasletmdkavqrfrlqn
    pdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqls
    qaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtn
    vpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfps
    afcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftld
    ptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpn
    nipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplf
    prlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgr
    atgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglp
    vavqcvalpwqeelclrfmreveqlmtpqkqps
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wj1A (A:)
    rqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgelsp
    eavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghdst
    lglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkssks
    pggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvygq
    tavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyyetd
    nytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqnfk
    gdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqheiem
    yrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvttvt
    aeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveqlmt
    pqk
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2wj1B (B:)
    mgsshhhhhhssglvprgshmasrwtgrqkargaatrarqkqrasletmdkavqrfrlqn
    pdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtncvtsyltdcetqls
    qaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvqvlklqgavpfvhtn
    vpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggsplglgtdiggsirfps
    afcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslalclkallcehlftld
    ptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqrleaaghtlipflpn
    nipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlpswfkrllslllkplf
    prlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvlltpmlgpaldlntpgr
    atgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwdiilkkamknsvglp
    vavqcvalpwqeelclrfmreveqlmtpqkqps
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wj1B (B:)
    rqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgelsp
    eavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghdst
    lglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkssks
    pggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvygq
    tavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyyetd
    nytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqnfk
    gdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqheiem
    yrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvttvt
    aeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveqlmt
    pqkq