PDB entry 2wi9

View 2wi9 on RCSB PDB site
Description: selective oxidation of carbolide c-h bonds by engineered macrolide p450 monooxygenase
Class: oxidoreductase
Keywords: antibiotic biosynthesis, cyp107l1, cytochrome p450, heme, iron, macrolide monooxygenase, metal-binding, monooxygenase, oxidoreductase, oxidoreductase antibiotic biosynthesis, pikc
Deposited on 2009-05-08, released 2009-10-27
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-11-24, with a file datestamp of 2009-11-20.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.189
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cytochrome p450 hydroxylase pikc
    Species: STREPTOMYCES VENEZUELAE [TaxId:54571]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WI9
      • engineered mutation (69)
    • Uniprot O87605
    Domains in SCOPe 2.08: d2wi9a_
  • Chain 'B':
    Compound: cytochrome p450 hydroxylase pikc
    Species: STREPTOMYCES VENEZUELAE [TaxId:54571]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WI9
      • engineered mutation (69)
    • Uniprot O87605
    Domains in SCOPe 2.08: d2wi9b_
  • Heterogens: HEM, 1D2, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2wi9A (A:)
    mgsshhhhhhssglvpagshmrrtqqgttasppvldlgalgqdfaadpyptyarlraegp
    ahrvrtpegnevwlvvgydraravladprfskdwrnsttplteaeaalnhnmlesdpprh
    trlrklvareftmrrvellrprvqeivdglvdamlaapdgradlmeslawplpitvisel
    lgvpepdraafrvwtdafvfpddpaqaqtamaemsgylsrlidskrgqdgedllsalvrt
    sdedgsrltseellgmahillvaghettvnliangmyallshpdqlaalradmtlldgav
    eemlryegpvesatyrfpvepvdldgtvipagdtvlvvladahrtperfpdphrfdirrd
    taghlafghgihfcigaplarleariavrallercpdlaldvspgelvwypnpmirglka
    lpirwrrgreagrrtg
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wi9A (A:)
    ppvldlgalgqdfaadpyptyarlraegpahrvrtpegnevwlvvgydraravladprfs
    kdwrnsttplteaeaalnhnmlesdpprhtrlrklvareftmrrvellrprvqeivdglv
    damlaapdgradlmeslawplpitvisellgvpepdraafrvwtdafvfpddpaqaqtam
    aemsgylsrlidskrgqdgedllsalvrtsdedgsrltseellgmahillvaghettvnl
    iangmyallshpdqlaalradmtlldgaveemlryegpvesatyrfpvepvdldgtvipa
    gdtvlvvladahrtperfpdphrfdirrdtaghlafghgihfcigaplarleariavral
    lercpdlaldvspgelvwypnpmirglkalpirwrr
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2wi9B (B:)
    mgsshhhhhhssglvpagshmrrtqqgttasppvldlgalgqdfaadpyptyarlraegp
    ahrvrtpegnevwlvvgydraravladprfskdwrnsttplteaeaalnhnmlesdpprh
    trlrklvareftmrrvellrprvqeivdglvdamlaapdgradlmeslawplpitvisel
    lgvpepdraafrvwtdafvfpddpaqaqtamaemsgylsrlidskrgqdgedllsalvrt
    sdedgsrltseellgmahillvaghettvnliangmyallshpdqlaalradmtlldgav
    eemlryegpvesatyrfpvepvdldgtvipagdtvlvvladahrtperfpdphrfdirrd
    taghlafghgihfcigaplarleariavrallercpdlaldvspgelvwypnpmirglka
    lpirwrrgreagrrtg
    

    Sequence, based on observed residues (ATOM records): (download)
    >2wi9B (B:)
    vldlgalgqdfaadpyptyarlraegpahrvrtpegnevwlvvgydraravladprfskd
    wrnsttplteaeaalnhnmlesdpprhtrlrklvareftmrrvellrprvqeivdglvda
    mlaapdgradlmeslawplpitvisellgvpepdraafrvwtdafvfpddpaqaqtamae
    msgylsrlidskrgqdgedllsalvrtsdedgsrltseellgmahillvaghettvnlia
    ngmyallshpdqlaalradmtlldgaveemlryegpvesatyrfpvepvdldgtvipagd
    tvlvvladahrtperfpdphrfdirrdtaghlafghgihfcigaplarleariavralle
    rcpdlaldvspgelvwypnpmirglkalpirwrr