PDB entry 2wi5

View 2wi5 on RCSB PDB site
Description: orally active 2-amino thienopyrimidine inhibitors of the hsp90 chaperone
Class: chaperone
Keywords: pu3, hsp90, ATPase, chaperone, heat shock, stress response, nucleotide-binding, ATP-binding, phosphoprotein, phosphorylation
Deposited on 2009-05-08, released 2009-07-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-08-10, with a file datestamp of 2011-08-05.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.22282
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Heat shock protein HSP 90-alpha
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2wi5a_
  • Heterogens: ZZ5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wi5A (A:)
mpeetqtqdqpmeeeevetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkir
yesltdpskldsgkelhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafme
alqagadismigqfgvgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepm
grgtkvilhlkedqteyleerrikeivkkhsqfigypitlfvekerdkevsddeae

    Sequence, based on observed residues (ATOM records): (download) 
    >2wi5A (A:)
evetfafqaeiaqlmsliintfysnkeiflrelisnssdaldkiryesltdpskldsgke
lhinlipnkqdrtltivdtgigmtkadlinnlgtiaksgtkafmealqagadismigqfg
vgfysaylvaekvtvitkhnddeqyawessaggsftvrtdtgepmgrgtkvilhlkedqt
eyleerrikeivkkhsqfigypitlfvek