PDB entry 2who

View 2who on RCSB PDB site
Description: crystal structure of hepatitis c virus ns5b polymerase from 1b genotype in complex with a non-nucleoside inhibitor
Class: transferase
Keywords: transferase, RNA replication, envelope protein, hepatitis c virus, endoplasmic reticulum, non nucleoside inhibitor, viral protein, metal-binding, transmembrane, polymerase, ATP-binding, genotype 1b, RNA-binding, RNA-dependent RNA polymerase, nni, hcv, ns5b, membrane, helicase, hydrolase, nucleotide-binding, allosteric inhibitor, RNA-directed RNA polymerase
Deposited on 2009-05-05, released 2009-08-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-01-23, with a file datestamp of 2019-01-18.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: HEPATITIS C VIRUS [TaxId:11105]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2whoa_
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: HEPATITIS C VIRUS [TaxId:11105]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2whob_
  • Heterogens: MN, VGI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2whoA (A:)
    smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
    ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
    svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
    tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
    qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
    aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
    elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
    armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
    einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkl
    

    Sequence, based on observed residues (ATOM records): (download)
    >2whoA (A:)
    smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
    ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
    svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
    tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
    qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
    aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
    elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
    armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
    einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavk
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2whoB (B:)
    smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
    ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
    svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
    tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
    qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
    aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
    elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
    armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
    einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkl
    

    Sequence, based on observed residues (ATOM records): (download)
    >2whoB (B:)
    smsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqvl
    ddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhih
    svwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
    tlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesiy
    qccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkas
    aacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeydl
    elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptlw
    armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsyspg
    einrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavk