PDB entry 2whh
View 2whh on RCSB PDB site
Description: hiv-1 protease tethered dimer q-product complex along with nucleophilic water molecule
Class: hydrolase
Keywords: protease, hydrolase, drug design, transferase, nucleotidyltransferase, RNA-directed DNA polymerase, catalytic mechanism, multifunctional enzyme, transition state, aspartyl protease
Deposited on
2009-05-05, released
2009-12-01
The last revision prior to the SCOPe 2.04 freeze date was dated
2010-06-23, with a file datestamp of
2010-06-18.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: 0.2193
AEROSPACI score: 0.52
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: pol protein
Species: Human immunodeficiency virus 1 [TaxId:11676]
Database cross-references and differences (RAF-indexed):
- Uniprot Q9QJ78 (104-202)
- conflict (2)
- conflict (61)
- conflict (94)
- conflict (106)
- conflict (165)
- engineered mutation (198)
- PDB 2WHH
Domains in SCOPe 2.04: d2whha1, d2whha2 - Heterogens: GLU, PPN, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2whhA (A:)
pqvtlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
qilieicghkaigtvlvgptpvniigrnlltqigmtlnfggssgpqvtlwqrplvtikig
gqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqydqilieicghkaigtvl
vgptpvniigrnlltqigatlnf
Sequence, based on observed residues (ATOM records): (download)
>2whhA (A:)
pqvtlwqrplvtikiggqlkealldtgaddtvleemslpgrwkpkmiggiggfikvrqyd
qilieicghkaigtvlvgptpvniigrnlltqigmtlnfpqvtlwqrplvtikiggqlke
alldtgaddtvleemslpgrwkpkmiggiggfikvrqydqilieicghkaigtvlvgptp
vniigrnlltqigatlnf