PDB entry 2wcx

View 2wcx on RCSB PDB site
Description: crystal structure of hepatitis c virus ns5b polymerase in complex with thienopyrrole-based finger-loop inhibitors
Class: hydrolase
Keywords: envelope protein, hepatitis c virus, RNA-dependent RNA-polymerase, nucleotide-binding, allosteric inhibitor, non nucleoside inhibitor, nni, hcv, ns5b, membrane, helicase, hydrolase, polymerase, ATP-binding, RNA-binding, genotype 1b, viral protein, transmembrane, RNA replication
Deposited on 2009-03-17, released 2009-08-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-11-23, with a file datestamp of 2011-11-18.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.16931
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: HEPATITIS C VIRUS [TaxId:11105]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WCX
    • Uniprot P26663 (1-End)
    Domains in SCOPe 2.08: d2wcxa_
  • Heterogens: MN, VGC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wcxA (A:)
msmsytwtgalitpcaaeesklpinalsnsllrhhnmvyattsrsaglrqkkvtfdrlqv
lddhyrdvlkemkakastvkakllsveeackltpphsakskfgygakdvrnlsskavnhi
hsvwkdlledtvtpidttimaknevfcvqpekggrkparlivfpdlgvrvcekmalydvv
stlpqvvmgssygfqyspgqrveflvntwkskknpmgfsydtrcfdstvtendirveesi
yqccdlapearqaikslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylka
saacraaklqdctmlvngddlvvicesagtqedaaslrvfteamtrysappgdppqpeyd
lelitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpvnswlgniimyaptl
warmilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsafslhsysp
geinrvasclrklgvpplrvwrhrarsvrarllsqggraatcgkylfnwavktklkl

    Sequence, based on observed residues (ATOM records): (download) 
    >2wcxA (A:)
smsytwtgalitpcaaeesklmvyattsrsaglrqkkvtfdrlqvlddhyrdvlkemkak
astvkakllsveeackltpphsakskfgygakdvrnlsskavnhihsvwkdlledtvtpi
dttimaknevfcvgrkparlivfpdlgvrvcekmalydvvstlpqvvmgssygfqyspgq
rveflvntwkskknpmgfsydtrcfdstvtendirveesiyqccdlapearqaikslter
lyiggpltnskgqncgyrrcrasgvlttscgntltcylkasaacraaklqdctmlvngdd
lvvicesagtqedaaslrvfteamtrysappgdppqpeydlelitscssnvsvahdasgk
rvyyltrdpttplaraawetarhtpvnswlgniimyaptlwarmilmthffsillaqeql
ekaldcqiygacysiepldlpqiierlhglsafslhsyspgeinrvasclrklgvpplrv
wrhrarsvrarllsqggraatcgkylfnwavk