PDB entry 2wcg

View 2wcg on RCSB PDB site
Description: x-ray structure of acid-beta-glucosidase with n-octyl(cyclic guanidine)-nojirimycin in the active site
Deposited on 2009-03-12, released 2009-11-24
The last revision was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WCG (499-End)
    • Uniprot B2R6A7 (2-498)
  • Chain 'B':
    Compound: glucosylceramidase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WCG
    • Uniprot B2R6A7 (2-498)
  • Heterogens: FUC, SO4, MT5, CL, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2wcgA (A:)
efarpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqa
nhtgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyni
irvpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllasp
wtsptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsa
gllsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltd
peaakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswd
rgmqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfy
hlghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavg
fletispgysihtylwhrqllvdtm

    Sequence, based on observed residues (ATOM records):
    >2wcgA (A:)
arpcipksfgyssvvcvcnatycdsfpalgtfsryestrsgrrmelsmgpiqanhtgtgl
lltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniirvpmas
cdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwtsptwl
ktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagllsgyp
fqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpeaakyv
hgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrgmqysh
siitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhlghfsk
fipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfletisp
gysihtylwhrql

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2wcgB (B:)
efarpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqa
nhtgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyni
irvpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllasp
wtsptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsa
gllsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltd
peaakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswd
rgmqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfy
hlghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavg
fletispgysihtylwhrqllvdtm

    Sequence, based on observed residues (ATOM records):
    >2wcgB (B:)
farpcipksfgyssvvcvcnatycdsfdppalgtfsryestrsgrrmelsmgpiqanhtg
tgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniirvp
mascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwtsp
twlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsaglls
gypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpeaa
kyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrgmq
yshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhlgh
fskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgflet
ispgysihtylwhrq