PDB entry 2wc0

View 2wc0 on RCSB PDB site
Description: crystal structure of human insulin degrading enzyme in complex with iodinated insulin
Deposited on 2009-03-06, released 2009-03-24
The last revision was dated 2009-05-26, with a file datestamp of 2009-05-22.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.172
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WC0
      • engineered mutation (80-81)
      • engineered mutation (141)
      • engineered mutation (148)
      • engineered mutation (227)
      • engineered mutation (384)
      • engineered mutation (543)
      • engineered mutation (560)
      • engineered mutation (759)
      • engineered mutation (782)
      • engineered mutation (789)
      • engineered mutation (874)
    • Uniprot P14735
  • Chain 'B':
    Compound: Insulin-degrading enzyme
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2WC0
      • engineered mutation (80-81)
      • engineered mutation (141)
      • engineered mutation (148)
      • engineered mutation (227)
      • engineered mutation (384)
      • engineered mutation (543)
      • engineered mutation (560)
      • engineered mutation (759)
      • engineered mutation (782)
      • engineered mutation (789)
      • engineered mutation (874)
    • Uniprot P14735
  • Chain 'C':
    Compound: insulin A chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'D':
    Compound: insulin B chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Chain 'E':
    Compound: insulin A chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Chain 'F':
    Compound: insulin B chain
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
  • Heterogens: ZN, DIO, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2wc0A (A:)
    mhhhhhhaagipmnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaa
    ldvhigslsdppniaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtny
    yfdvshehlegaldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatg
    npkhpfskfgtgnkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltn
    lvvklfsevenknvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksn
    pghylghlighegpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhved
    iilhmfqyiqklraegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleev
    ltaeylleefrpdliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdev
    ikkwqnadlngkfklptknefiptnfeilplekeatpypalikdtamsklwfkqddkffl
    pkanlnfeffspfayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmyl
    svkgyndkqpillkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrll
    mtevawtkdelkealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtl
    iehahtkpllpsqlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmfle
    lfaqiisepafntlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflit
    meksiedmteeafqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylk
    tltkediikfykemlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqp
    eviqnmtefkrglplfplvkphinfmaakl
    

    Sequence, based on observed residues (ATOM records):
    >2wc0A (A:)
    nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
    iaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
    drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
    kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
    vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
    pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
    aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
    liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
    klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
    ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
    kkiiekmatfeidekrfeiikeaymrslnnfraeqphhamyylrllmtevawtkdelkea
    lddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsql
    vryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafntl
    rtkeqlgyivfsgprrangiqglrfiiqsekppylesrveaflitmeksiedmteeafqk
    hiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfykeml
    avdaprrhkvsvhvlaremnlsqapalpqpeviqnmtefkrglplfplvkphi
    

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2wc0B (B:)
    mhhhhhhaagipmnnpaikrignhitkspedkreyrglelangikvllisdpttdkssaa
    ldvhigslsdppniaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtny
    yfdvshehlegaldrfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatg
    npkhpfskfgtgnkytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltn
    lvvklfsevenknvplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksn
    pghylghlighegpgsllselkskgwvntlvggqkegargfmffiinvdlteegllhved
    iilhmfqyiqklraegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleev
    ltaeylleefrpdliemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdev
    ikkwqnadlngkfklptknefiptnfeilplekeatpypalikdtamsklwfkqddkffl
    pkanlnfeffspfayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmyl
    svkgyndkqpillkkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrll
    mtevawtkdelkealddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtl
    iehahtkpllpsqlvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmfle
    lfaqiisepafntlrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflit
    meksiedmteeafqkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylk
    tltkediikfykemlavdaprrhkvsvhvlaremdsnpvvgefpaqndinlsqapalpqp
    eviqnmtefkrglplfplvkphinfmaakl
    

    Sequence, based on observed residues (ATOM records):
    >2wc0B (B:)
    nnpaikrignhitkspedkreyrglelangikvllisdpttdkssaaldvhigslsdppn
    iaglshflqhmlflgtkkypkeneysqflsehagssnaftsgehtnyyfdvshehlegal
    drfaqfflsplfdesakdrevnavdseheknvmndawrlfqlekatgnpkhpfskfgtgn
    kytletrpnqegidvrqellkfhsayyssnlmavvvlgreslddltnlvvklfsevenkn
    vplpefpehpfqeehlkqlykivpikdirnlyvtfpipdlqkyyksnpghylghligheg
    pgsllselkskgwvntlvggqkegargfmffiinvdlteegllhvediilhmfqyiqklr
    aegpqewvfqelkdlnavafrfkdkerprgytskiagilhyypleevltaeylleefrpd
    liemvldklrpenvrvaivsksfegktdrteewygtqykqeaipdevikkwqnadlngkf
    klptknefiptnfeilplekeatpypalikdtamsklwfkqddkfflpkanlnfeffspf
    ayvdplhsnmaylylellkdslneyayaaelaglsydlqntiygmylsvkgyndkqpill
    kkiiekmatfeidekrfeiikeaymrslnnfraeqphqhamyylrllmtevawtkdelke
    alddvtlprlkafipqllsrlhieallhgnitkqaalgimqmvedtliehahtkpllpsq
    lvryrevqlpdrgwfvyqqrnevhnnsgieiyyqtdmqstsenmflelfaqiisepafnt
    lrtkeqlgyivfsgprrangiqglrfiiqsekpphylesrveaflitmeksiedmteeaf
    qkhiqalairrldkpkklsaesakywgeiisqqynfdrdntevaylktltkediikfyke
    mlavdaprrhkvsvhvlaremnlsqapalpqpeviqnmtefkrglplfplvkphi
    

  • Chain 'C':
    Sequence; same for both SEQRES and ATOM records:
    >2wc0C (C:)
    giveqcctsicslyqlenycn
    

  • Chain 'D':
    Sequence, based on SEQRES records:
    >2wc0D (D:)
    fvnqhlcgshlvealylvcgergffytpkt
    

    Sequence, based on observed residues (ATOM records):
    >2wc0D (D:)
    fvnqhlcgshlvealylvcg
    

  • Chain 'E':
    Sequence; same for both SEQRES and ATOM records:
    >2wc0E (E:)
    giveqcctsicslyqlenycn
    

  • Chain 'F':
    Sequence, based on SEQRES records:
    >2wc0F (F:)
    fvnqhlcgshlvealylvcgergffytpkt
    

    Sequence, based on observed residues (ATOM records):
    >2wc0F (F:)
    fvnqhlcgshlvealylvcg