PDB entry 2wap

View 2wap on RCSB PDB site
Description: 3d-crystal structure of humanized-rat fatty acid amide hydrolase (faah) conjugated with the drug-like urea inhibitor pf-3845
Class: hydrolase
Keywords: fatty acid amide hydrolase, urea inhibitor, golgi apparatus, endoplasmic reticulum, acyl- enzyme, transmembrane, phosphoprotein, faah, drug, membrane, hydrolase, inhibitor
Deposited on 2009-02-11, released 2009-05-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-11-10, with a file datestamp of 2009-11-06.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.194
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fatty-acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P97612 (Start-542)
      • engineered mutation (161)
      • engineered mutation (163)
      • engineered mutation (346)
      • engineered mutation (404)
      • engineered mutation (460)
      • engineered mutation (464)
    Domains in SCOPe 2.08: d2wapa_
  • Chain 'B':
    Compound: fatty-acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P97612 (0-542)
      • engineered mutation (161)
      • engineered mutation (163)
      • engineered mutation (346)
      • engineered mutation (404)
      • engineered mutation (460)
      • engineered mutation (464)
    Domains in SCOPe 2.08: d2wapb_
  • Heterogens: PIX, CL, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2wapA (A:)
wtgrqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsge
lspeavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykgh
dstlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwks
skspggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcv
ygqtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyy
etdnytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflq
nfkgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqhe
iemyrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvt
tvtaeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveq
lmt

    Sequence, based on observed residues (ATOM records): (download) 
    >2wapA (A:)
grqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgels
peavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghds
tlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkssk
spggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvyg
qtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyyet
dnytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqnf
kgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqheie
myrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvttv
taeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveqlm
t

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2wapB (B:)
wtgrqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsge
lspeavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykgh
dstlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwks
skspggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcv
ygqtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyy
etdnytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflq
nfkgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqhe
iemyrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvt
tvtaeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveq
lmt