PDB entry 2w9s

View 2w9s on RCSB PDB site
Description: staphylococcus aureus s1:dhfr in complex with trimethoprim
Class: oxidoreductase
Keywords: antibiotic resistance, dhfr, nadp, oxidoreductase, trimethoprim resistance, one-carbon metabolism, methotrexate resistance
Deposited on 2009-01-28, released 2009-03-24
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-04-20, with a file datestamp of 2011-04-15.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.2037
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase type 1 from tn4003
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13955
      • engineered mutation (48)
      • engineered mutation (130)
    Domains in SCOPe 2.08: d2w9sa_
  • Chain 'B':
    Compound: dihydrofolate reductase type 1 from tn4003
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13955
      • engineered mutation (48)
      • engineered mutation (130)
    Domains in SCOPe 2.08: d2w9sb_
  • Chain 'C':
    Compound: dihydrofolate reductase type 1 from tn4003
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13955
      • engineered mutation (48)
      • engineered mutation (130)
    Domains in SCOPe 2.08: d2w9sc_
  • Chain 'D':
    Compound: dihydrofolate reductase type 1 from tn4003
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13955
      • engineered mutation (48)
      • engineered mutation (130)
    Domains in SCOPe 2.08: d2w9sd_
  • Chain 'E':
    Compound: dihydrofolate reductase type 1 from tn4003
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13955
      • engineered mutation (48)
      • engineered mutation (130)
    Domains in SCOPe 2.08: d2w9se_
  • Chain 'F':
    Compound: dihydrofolate reductase type 1 from tn4003
    Species: Staphylococcus aureus [TaxId:1280]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P13955
      • engineered mutation (48)
      • engineered mutation (130)
    Domains in SCOPe 2.08: d2w9sf_
  • Heterogens: GOL, NDP, TOP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2w9sA (A:)
mtlsiivahdkqrvigyqnqlpwhlpndlkhikqlttgntlvmarktfesigkplpnrrn
vvltnqasfhhegvdvinsldeikelsghvfifggqtlyeamidqvddmyitvidgkfqg
dtffppytfedwevessvegqldekntiphtflhlvrrkgk

    Sequence, based on observed residues (ATOM records): (download) 
    >2w9sA (A:)
tlsiivahdkqrvigyqnqlpwhlpndlkhikqlttgntlvmarktfesigkplpnrrnv
vltnqasfhhegvdvinsldeikelsghvfifggqtlyeamidqvddmyitvidgkfqgd
tffppytfedwevessvegqldekntiphtflhlvrr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2w9sB (B:)
mtlsiivahdkqrvigyqnqlpwhlpndlkhikqlttgntlvmarktfesigkplpnrrn
vvltnqasfhhegvdvinsldeikelsghvfifggqtlyeamidqvddmyitvidgkfqg
dtffppytfedwevessvegqldekntiphtflhlvrrkgk

    Sequence, based on observed residues (ATOM records): (download) 
    >2w9sB (B:)
tlsiivahdkqrvigyqnqlpwhlpndlkhikqlttgntlvmarktfesigkplpnrrnv
vltnqasfhhegvdvinsldeikelsghvfifggqtlyeamidqvddmyitvidgkfqgd
tffppytfedwevessvegqldekntiphtflhlvrr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2w9sC (C:)
mtlsiivahdkqrvigyqnqlpwhlpndlkhikqlttgntlvmarktfesigkplpnrrn
vvltnqasfhhegvdvinsldeikelsghvfifggqtlyeamidqvddmyitvidgkfqg
dtffppytfedwevessvegqldekntiphtflhlvrrkgk

    Sequence, based on observed residues (ATOM records): (download) 
    >2w9sC (C:)
tlsiivahdkqrvigyqnqlpwhlpndlkhikqlttgntlvmarktfesigkplpnrrnv
vltnqasfhhegvdvinsldeikelsghvfifggqtlyeamidqvddmyitvidgkfqgd
tffppytfedwevessvegqldekntiphtflhlvrr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2w9sD (D:)
mtlsiivahdkqrvigyqnqlpwhlpndlkhikqlttgntlvmarktfesigkplpnrrn
vvltnqasfhhegvdvinsldeikelsghvfifggqtlyeamidqvddmyitvidgkfqg
dtffppytfedwevessvegqldekntiphtflhlvrrkgk

    Sequence, based on observed residues (ATOM records): (download) 
    >2w9sD (D:)
tlsiivahdkqrvigyqnqlpwhlpndlkhikqlttgntlvmarktfesigkplpnrrnv
vltnqasfhhegvdvinsldeikelsghvfifggqtlyeamidqvddmyitvidgkfqgd
tffppytfedwevessvegqldekntiphtflhlvrr

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >2w9sE (E:)
mtlsiivahdkqrvigyqnqlpwhlpndlkhikqlttgntlvmarktfesigkplpnrrn
vvltnqasfhhegvdvinsldeikelsghvfifggqtlyeamidqvddmyitvidgkfqg
dtffppytfedwevessvegqldekntiphtflhlvrrkgk

    Sequence, based on observed residues (ATOM records): (download) 
    >2w9sE (E:)
tlsiivahdkqrvigyqnqlpwhlpndlkhikqlttgntlvmarktfesigkplpnrrnv
vltnqasfhhegvdvinsldeikelsghvfifggqtlyeamidqvddmyitvidgkfqgd
tffppytfedwevessvegqldekntiphtflhlvrr

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >2w9sF (F:)
mtlsiivahdkqrvigyqnqlpwhlpndlkhikqlttgntlvmarktfesigkplpnrrn
vvltnqasfhhegvdvinsldeikelsghvfifggqtlyeamidqvddmyitvidgkfqg
dtffppytfedwevessvegqldekntiphtflhlvrrkgk

    Sequence, based on observed residues (ATOM records): (download) 
    >2w9sF (F:)
tlsiivahdkqrvigyqnqlpwhlpndlkhikqlttgntlvmarktfesigkplpnrrnv
vltnqasfhhegvdvinsldeikelsghvfifggqtlyeamidqvddmyitvidgkfqgd
tffppytfedwevessvegqldekntiphtflhlvrr