PDB entry 2w9f
View 2w9f on RCSB PDB site
Description: crystal structure of cdk4 in complex with a d-type cyclin
Class: cell cycle
Keywords: serine/threonine-protein kinase, chromosomal rearrangement, ATP-binding, transferase, polymorphism, cell division, proto-oncogene, phosphoprotein, disease mutation, nucleotide-binding, cyclin dependent kinase, kinase, cyclin, oncology, cell cycle, drug desgn
Deposited on
2009-01-23, released
2009-03-10
The last revision prior to the SCOPe 2.05 freeze date was dated
2009-03-31, with a file datestamp of
2009-03-27.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: 0.229
AEROSPACI score: 0.21
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: g1/s-specific cyclin-d1
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Chain 'B':
Compound: cell division protein kinase 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P11802 (44-End)
- engineered mutation (42-43)
- PDB 2W9F
Domains in SCOPe 2.05: d2w9fb_ - Heterogens: HOH
PDB Chain Sequences:
- Chain 'A':
No sequence available.
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2w9fB (B:)
matsryepvaeigvgaygtvykardphsghfvalksvrvpngeeglpistvrevallrrl
eafehpnvvrlmdvcatsrtdreikvtlvfehvdqdlrtyldkapppglpaetikdlmrq
flrgldflhancivhrdlkpenilvtsggtvkladfglariysyqmalfpvvvtlwyrap
evllqstyatpvdmwsvgcifaemfrrkplfcgnseadqlgkifdliglppeddwprdvs
lprgafpprgprpvqsvvpemeesgaqlllemltfnphkrisafralqhsylhkdegnpe
hhhhhh
Sequence, based on observed residues (ATOM records): (download)
>2w9fB (B:)
ryepvaeigvgaygtvykardphsghfvalksvrvpngeeglpistvrevallrrleafe
hpnvvrlmdvcatsrtdreikvtlvfehvdqdlrtyldkapppglpaetikdlmrqflrg
ldflhancivhrdlkpenilvtsggtvkladfglariysyqmatlwyrapevllqstyat
pvdmwsvgcifaemfrrkplfcgnseadqlgkifdligwprdvssvvpemeesgaqllle
mltfnphkrisafralqhsyl