PDB entry 2w7x

View 2w7x on RCSB PDB site
Description: cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel chk2 inhibitor pv1019
Class: transferase
Keywords: co-crystal structure, kinase, nucleus, magnesium, cell cycle, ATP-binding, li-fraumeni syndrome, serine/threonine-protein kinase, disease mutation, nucleotide-binding, transferase, potentiation, metal-binding, proto-oncogene, phosphoprotein, chk2 inhibitor
Deposited on 2009-01-06, released 2009-09-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-06-02.
Experiment type: XRAY
Resolution: 2.07 Å
R-factor: 0.195
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase chk2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2W7X
    • Uniprot O96017 (1-End)
    Domains in SCOPe 2.06: d2w7xa_
  • Heterogens: D1A, MG, NO3, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2w7xA (A:)
msvypkalrdeyimsktlgsgacgevklaferktckkvaikiiskrkfaigsareadpal
nveteieilkklnhpciikiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyf
yqmllavqylhengiihrdlkpenvllssqeedclikitdfghskilgetslmrtlcgtp
tylapevlvsvgtagynravdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfi
pevwaevsekaldlvkkllvvdpkarftteealrhpwlqdedmkrkfqdllseenestal
pqvlaqpstsrkrpregeaegae

    Sequence, based on observed residues (ATOM records): (download) 
    >2w7xA (A:)
svypkalrdeyimsktlgsgagevklaferktckkvaikiisknveteieilkklnhpci
ikiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfyqmllavqylhengiih
rdlkpenvllssqeedclikitdfghskilgetslmrtlcgtptylapevlvsvgtagyn
ravdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfipevwaevsekaldlvkk
llvvdpkarftteealrhpwlqdedmkrkfqdllseenestalpq