PDB entry 2w3w

View 2w3w on RCSB PDB site
Description: mycobacterium avium dihydrofolate reductase complexed with nadph and a lipophilic antifolate selective for m. avium dhfr, 6-((2,5-diethoxyphenyl)aminomethyl)-2,4-diamino-5-methylpyrido(2,3-d)pyrimidine (sri-8686)
Class: oxidoreductase
Keywords: nonclassical antifolates, one-carbon metabolism, lipophilic antifolates, nadp, reductase, oxidoreductase
Deposited on 2008-11-16, released 2009-11-17
The last revision prior to the SCOPe 2.05 freeze date was dated 2011-07-13, with a file datestamp of 2011-06-02.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.175
AEROSPACI score: 0.6 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Mycobacterium avium [TaxId:1764]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2w3wa_
  • Heterogens: VG9, NDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2w3wA (A:)
mtraevglvwaqstsgvigrggdipwsvpedltrfkevtmghtvimgrrtweslpakvrp
lpgrrnvvvsrrpdfvaegarvagsleaalayagsdpapwviggaqiyllalphatrcev
teieidlrrddddalapalddswvgetgewlasrsglryrfhsyrrd

    Sequence, based on observed residues (ATOM records): (download) 
    >2w3wA (A:)
raevglvwaqstsgvigrggdipwsvpedltrfkevtmghtvimgrrtweslpakvrplp
grrnvvvsrrpdfvaegarvagsleaalayagsdpapwviggaqiyllalphatrcevte
ieidlrrddddalapalddswvgetgewlasrsglryrfhsyrrd