PDB entry 2w3l

View 2w3l on RCSB PDB site
Description: crystal structure of chimaeric bcl2-xl and phenyl tetrahydroisoquinoline amide complex
Class: apoptosis
Keywords: apoptosis
Deposited on 2008-11-13, released 2008-12-09
The last revision prior to the SCOPe 2.05 freeze date was dated 2008-12-23, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.218
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Apoptosis regulator Bcl-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415 (29-143)
      • conflict (32)
      • conflict (36)
      • conflict (55)
    • PDB 2W3L (Start-28)
    Domains in SCOPe 2.05: d2w3la_
  • Chain 'B':
    Compound: Apoptosis regulator Bcl-2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P10415 (29-End)
      • conflict (32)
      • conflict (36)
      • conflict (55)
    • PDB 2W3L (25-28)
    Domains in SCOPe 2.05: d2w3lb_
  • Heterogens: DRO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2w3lA (A:)
ydnreivmkyihyklsqrgyewdagadsevvhktlreagddfsrryrrdfaemssglhlt
pftargrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteyln
rhlhtwiqdnggwdafvelygpsm

    Sequence, based on observed residues (ATOM records): (download) 
    >2w3lA (A:)
ydnreivmkyihyklsqrgyewdasevvhktlreagddfsrryrrdfaemssglhltpft
argrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteylnrhl
htwiqdnggwdafvelygpsm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2w3lB (B:)
ydnreivmkyihyklsqrgyewdagadsevvhktlreagddfsrryrrdfaemssglhlt
pftargrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteyln
rhlhtwiqdnggwdafvelygpsm

    Sequence, based on observed residues (ATOM records): (download) 
    >2w3lB (B:)
ydnreivmkyihyklsqrgyewdagadsevvhktlreagddfsrryrrdfaemssglhlt
pftargrfatvveelfrdgvnwgrivaffefggvmcvesvnremsplvdnialwmteyln
rhlhtwiqdnggwdafvelygp