PDB entry 2w3i

View 2w3i on RCSB PDB site
Description: crystal structure of fxa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 2
Class: hydrolase
Keywords: drug design, glycoprotein, hydroxylation, blood clotting, serine protease, egf-like domain, fxa coagulation factor inhibitor, zymogen, protease, secreted, hydrolase, blood coagulation, gamma-carboxyglutamic acid, cleavage on pair of basic residues
Deposited on 2008-11-12, released 2009-04-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-06-02.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.222
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: coagulation factor x, heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2w3ia_
  • Chain 'B':
    Compound: coagulation factor x, light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2w3ib_
  • Heterogens: CA, L1C, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2w3iA (A:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2w3iB (B:)
lcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtle

    Sequence, based on observed residues (ATOM records): (download) 
    >2w3iB (B:)
lcsldngdcdqfcheeqnsvvcscargytladngkaciptpypcgkqtle