PDB entry 2w3b
View 2w3b on RCSB PDB site
Description: human dihydrofolate reductase complexed with nadph and a lipophilic antifolate selective for mycobacterium avium dhfr, 6-((2,5- diethoxyphenyl)aminomethyl)-2,4-diamino-5-methylpyrido(2,3-d) pyrimidine (sri-8686)
Class: oxidoreductase
Keywords: nonclassical antifolates, one-carbon metabolism, lipophilic antifolates, nadp, reductase, oxidoreductase
Deposited on
2008-11-11, released
2009-11-17
The last revision prior to the SCOPe 2.08 freeze date was dated
2019-05-08, with a file datestamp of
2019-05-03.
Experiment type: XRAY
Resolution: 1.27 Å
R-factor: N/A
AEROSPACI score: 0.61
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: dihydrofolate reductase
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2w3ba_ - Chain 'B':
Compound: dihydrofolate reductase
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d2w3bb_ - Heterogens: NDP, VG9, FOL, K, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2w3bA (A:)
mvgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfs
ipeknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggss
vykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykf
evyeknd
Sequence, based on observed residues (ATOM records): (download)
>2w3bA (A:)
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyekn
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2w3bB (B:)
mvgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfs
ipeknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggss
vykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykf
evyeknd
Sequence, based on observed residues (ATOM records): (download)
>2w3bB (B:)
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd