PDB entry 2w2p
View 2w2p on RCSB PDB site
Description: pcsk9-deltac d374a mutant bound to wt egf-a of ldlr
Class: hydrolase/receptor
Keywords: hydrolase-receptor complex, pcsk9, ldlr, proprotein convertase, low-density lipoprotein receptor, egf, cardiovascular disease, familial hypercholesterolemia, lipid metabolism, serine protease, hydrolase, lipid transport, steroid metabolism, receptor
Deposited on
2008-11-03, released
2008-11-18
The last revision prior to the SCOPe 2.07 freeze date was dated
2011-07-13, with a file datestamp of
2011-06-02.
Experiment type: XRAY
Resolution: 2.62 Å
R-factor: 0.22803
AEROSPACI score: 0.27
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proprotein convertase subtilisin/kexin type 9
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8NBP7 (0-End)
- engineered mutation (221)
- PDB 2W2P
Domains in SCOPe 2.07: d2w2pa_ - Chain 'E':
Compound: low-density lipoprotein receptor
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2W2P (Start-26)
- Uniprot P01130 (27-End)
Domains in SCOPe 2.07: d2w2pe1, d2w2pe2 - Chain 'P':
Compound: Proprotein convertase subtilisin/kexin type 9
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- PDB 2W2P
- Uniprot Q8NBP7 (Start-113)
- Heterogens: CA, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2w2pA (A:)
sipwnleritppryradeyqppdggslvevylldtsiqsdhreiegrvmvtdfenvpeed
gtrfhrqaskcdshgthlagvvsgrdagvakgasmrslrvlncqgkgtvsgtliglefir
ksqlvqpvgplvvllplaggysrvlnaacqrlaragvvlvtaagnfrddaclyspasape
vitvgatnaqdqpvtlgtlgtnfgrcvdlfapgediigassacstcfvsqsgtsqaaahv
agiaammlsaepeltlaelrqrlihfsakdvineawfpedqrvltpnlvaalppsthgaa
gtaaashhhhhh
Sequence, based on observed residues (ATOM records): (download)
>2w2pA (A:)
sipwnleritpprlvevylldtsiqsdhreiegrvmvtdfenvpeedskcdshgthlagv
vsgrdagvakgasmrslrvlncqgkgtvsgtliglefirksqlvqpvgplvvllplaggy
srvlnaacqrlaragvvlvtaagnfrddaclyspasapevitvgatnaqdqpvtlgtlgt
nfgrcvdlfapgediigassacstcfvsqsgtsqaaahvagiaammlsaepeltlaelrq
rlihfsakdvineawfpedqrvltpnlvaalpps
- Chain 'E':
Sequence, based on SEQRES records: (download)
>2w2pE (E:)
mkhhhhhhpmsdydipttenlyfqgamgtnecldnnggcshvcndlkigyeclcpdgfql
vaqrrcedidecqdpdtcsqlcvnleggykcqceegfqldphtkack
Sequence, based on observed residues (ATOM records): (download)
>2w2pE (E:)
nlyfqgamgtnecldnnggcshvcndlkigyeclcpdgfqlvaqrrce
- Chain 'P':
No sequence available.