PDB entry 2w0d

View 2w0d on RCSB PDB site
Description: Does a Fast Nuclear Magnetic Resonance Spectroscopy- and X-Ray Crystallography Hybrid Approach Provide Reliable Structural Information of Ligand-Protein Complexes? A Case Study of Metalloproteinases.
Class: hydrolase
Keywords: glycoprotein, metal-binding, metalloprotease, secreted, hydrolase, hydroxamate, extracellular matrix, copd, mmp-12, zymogen
Deposited on 2008-08-13, released 2009-03-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-22, with a file datestamp of 2019-05-17.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Macrophage metalloelastase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P39900 (1-158)
      • expression tag (159)
      • engineered mutation (114)
    Domains in SCOPe 2.08: d2w0da1, d2w0da2
  • Chain 'B':
    Compound: Macrophage metalloelastase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P39900 (1-158)
      • expression tag (159)
      • engineered mutation (114)
    Domains in SCOPe 2.08: d2w0db1, d2w0db2
  • Chain 'C':
    Compound: Macrophage metalloelastase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P39900 (1-158)
      • expression tag (0)
      • expression tag (159)
      • engineered mutation (114)
    Domains in SCOPe 2.08: d2w0dc1, d2w0dc2, d2w0dc3
  • Chain 'D':
    Compound: Macrophage metalloelastase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P39900 (1-158)
      • expression tag (0)
      • expression tag (159)
      • engineered mutation (114)
    Domains in SCOPe 2.08: d2w0dd1, d2w0dd2, d2w0dd3
  • Heterogens: ZN, CA, ACT, CGS, CL, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2w0dA (A:)
    mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
    rgahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhaighsl
    glghssdpkavmfptykyvdintfrlsaddirgiqslyghhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >2w0dA (A:)
    gpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfar
    gahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhaighslg
    lghssdpkavmfptykyvdintfrlsaddirgiqslygh
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2w0dB (B:)
    mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
    rgahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhaighsl
    glghssdpkavmfptykyvdintfrlsaddirgiqslyghhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >2w0dB (B:)
    gpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfar
    gahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhaighslg
    lghssdpkavmfptykyvdintfrlsaddirgiqslygh
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >2w0dC (C:)
    mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
    rgahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhaighsl
    glghssdpkavmfptykyvdintfrlsaddirgiqslyghhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >2w0dC (C:)
    mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
    rgahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhaighsl
    glghssdpkavmfptykyvdintfrlsaddirgiqslygh
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >2w0dD (D:)
    mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
    rgahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhaighsl
    glghssdpkavmfptykyvdintfrlsaddirgiqslyghhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >2w0dD (D:)
    mgpvwrkhyityrinnytpdmnredvdyairkafqvwsnvtplkfskintgmadilvvfa
    rgahgdfhafdgkggilahafgpgsgiggdahfdedefwtthsggtnlfltavhaighsl
    glghssdpkavmfptykyvdintfrlsaddirgiqslygh