PDB entry 2vya

View 2vya on RCSB PDB site
Description: crystal structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor pf-750
Class: hydrolase
Keywords: hydrolase, fatty acid amide hydrolyse, golgi apparatus, endoplasmic reticulum, inhibitor, drug- like, transmembrane, faah, chimera, membrane, covalent, humanized
Deposited on 2008-07-22, released 2008-09-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-07-13, with a file datestamp of 2011-06-02.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: 0.191
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: fatty-acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VYA
      • engineered mutation (199)
      • engineered mutation (201)
      • engineered mutation (384)
      • engineered mutation (442)
      • engineered mutation (498)
      • engineered mutation (502)
    • Uniprot P97612
    Domains in SCOPe 2.08: d2vyaa_
  • Chain 'B':
    Compound: fatty-acid amide hydrolase 1
    Species: Rattus norvegicus [TaxId:10116]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VYA
      • engineered mutation (199)
      • engineered mutation (201)
      • engineered mutation (384)
      • engineered mutation (442)
      • engineered mutation (498)
      • engineered mutation (502)
    • Uniprot P97612
    Domains in SCOPe 2.08: d2vyab_
  • Heterogens: UNX, PF7, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vyaA (A:)
mgsshhhhhhssasmtggqqmgrtlyddddkdrwgseletgrqkargaatrarqkqrasl
etmdkavqrfrlqnpdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtn
cvtsyltdcetqlsqaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvq
vlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggspl
glgtdiggsirfpsafcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslal
clkallcehlftldptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqr
leaaghtlipflpnnipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlps
wfkrllslllkplfprlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvllt
pmlgpaldlntpgratgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwd
iilkkamknsvglpvavqcvalpwqeelclrfmreveqlmtpqkqps

    Sequence, based on observed residues (ATOM records): (download) 
    >2vyaA (A:)
grqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgels
peavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghds
tlglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkssk
spggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvyg
qtavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyyet
dnytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqnf
kgdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqheie
myrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvttv
taeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveqlm
tpq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vyaB (B:)
mgsshhhhhhssasmtggqqmgrtlyddddkdrwgseletgrqkargaatrarqkqrasl
etmdkavqrfrlqnpdldsealltlpllqlvqklqsgelspeavfftylgkawevnkgtn
cvtsyltdcetqlsqaprqgllygvpvslkecfsykghdstlglslnegmpsesdcvvvq
vlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwksskspggssggegaligsggspl
glgtdiggsirfpsafcgicglkptgnrlsksglkgcvygqtavqlslgpmardveslal
clkallcehlftldptvpplpfreevyrssrplrvgyyetdnytmpspamrralietkqr
leaaghtlipflpnnipyalevlstgglfsdggrsflqnfkgdfvdpclgdlililrlps
wfkrllslllkplfprlaaflnnmrprsaeklwklqheiemyrqsviaqwkamnldvllt
pmlgpaldlntpgratgavsytmlyncldfpagvvpvttvtaeddaqmelykgyfgdiwd
iilkkamknsvglpvavqcvalpwqeelclrfmreveqlmtpqkqps

    Sequence, based on observed residues (ATOM records): (download) 
    >2vyaB (B:)
rqkargaatrarqkqrasletmdkavqrfrlqnpdldsealltlpllqlvqklqsgelsp
eavfftylgkawevnkgtncvtsyltdcetqlsqaprqgllygvpvslkecfsykghdst
lglslnegmpsesdcvvvqvlklqgavpfvhtnvpqsmfsydcsnplfgqtmnpwkssks
pggssggegaligsggsplglgtdiggsirfpsafcgicglkptgnrlsksglkgcvygq
tavqlslgpmardveslalclkallcehlftldptvpplpfreevyrssrplrvgyyetd
nytmpspamrralietkqrleaaghtlipflpnnipyalevlstgglfsdggrsflqnfk
gdfvdpclgdlililrlpswfkrllslllkplfprlaaflnnmrprsaeklwklqheiem
yrqsviaqwkamnldvlltpmlgpaldlntpgratgavsytmlyncldfpagvvpvttvt
aeddaqmelykgyfgdiwdiilkkamknsvglpvavqcvalpwqeelclrfmreveqlmt
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