PDB entry 2vxm

View 2vxm on RCSB PDB site
Description: screening a limited structure-based library identifies udp-galnac-specific mutants of alpha-1,3 galactosyltransferase
Class: transferase
Keywords: glycosyltransferase, 3 galactosyltransferase, transmembrane, golgi apparatus, enzyme mechanism, glycoprotein, metal-binding, signal-anchor, alpha-1, membrane, manganese, transferase, glycosyltransferase galactosyltransferase, transferase substrate specificity
Deposited on 2008-07-07, released 2008-09-23
The last revision prior to the SCOPe 2.01 freeze date was dated 2008-12-09, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.82 Å
R-factor: 0.219
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: n-acetyllactosaminide alpha-1,3-galactosyltransferase
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14769 (0-272)
      • engineered mutation (198)
    Domains in SCOPe 2.01: d2vxma_
  • Chain 'B':
    Compound: n-acetyllactosaminide alpha-1,3-galactosyltransferase
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14769 (0-End)
      • engineered mutation (198)
    Domains in SCOPe 2.01: d2vxmb_
  • Chain 'C':
    Compound: n-acetyllactosaminide alpha-1,3-galactosyltransferase
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14769 (0-End)
      • engineered mutation (198)
    Domains in SCOPe 2.01: d2vxmc_
  • Chain 'D':
    Compound: n-acetyllactosaminide alpha-1,3-galactosyltransferase
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14769 (0-End)
      • engineered mutation (198)
    Domains in SCOPe 2.01: d2vxmd_
  • Heterogens: MPD, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vxmA (A:)
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hyleefltsankhfmvghpvifyimvddvsrmplielgplrsfkvfkikpekrwqdismm
rmktigehivahiqhevdflfcmdvdqvfqdkfgvetlgesvaqlqawwykadpndftye
rrkesaayipfgegdfyyraaifggtptqvlnitqecfkgilkdkkndieaqwhdeshln
kyfllnkptkilspeycwdyhiglpadiklvkm

    Sequence, based on observed residues (ATOM records): (download) 
    >2vxmA (A:)
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hyleefltsankhfmvghpvifyimvddvsrmplielgplrsfkvfkikpeismmrmkti
gehivahiqhevdflfcmdvdqvfqdkfgvetlgesvaqlqawwykadpndftyerrkes
aayipfgegdfyyraaifggtptqvlnitqecfkgilkdkkndieaqwhdeshlnkyfll
nkptkilspeycwdyhiglpadiklvkm

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vxmB (B:)
klklsdwfnpfkrpevvtmtkwkapvvwegtynravldnyyakqkitvgltvfavgryie
hyleefltsankhfmvghpvifyimvddvsrmplielgplrsfkvfkikpekrwqdismm
rmktigehivahiqhevdflfcmdvdqvfqdkfgvetlgesvaqlqawwykadpndftye
rrkesaayipfgegdfyyraaifggtptqvlnitqecfkgilkdkkndieaqwhdeshln
kyfllnkptkilspeycwdyhiglpadiklvkm

    Sequence, based on observed residues (ATOM records): (download) 
    >2vxmB (B:)
klklsdwfnpfkrpevvtmtkwkapvvwegtynravldnyyakqkitvgltvfavgryie
hyleefltsankhfmvghpvifyimvddvsrmplielgplrsfkvfkikpeismmrmkti
gehivahiqhevdflfcmdvdqvfqdkfgvetlgesvaqlqawwykadpndftyerrkes
aayipfgegdfyyraaifggtptqvlnitqecfkgilkdkkndieaqwhdeshlnkyfll
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  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2vxmC (C:)
klklsdwfnpfkrpevvtmtkwkapvvwegtynravldnyyakqkitvgltvfavgryie
hyleefltsankhfmvghpvifyimvddvsrmplielgplrsfkvfkikpekrwqdismm
rmktigehivahiqhevdflfcmdvdqvfqdkfgvetlgesvaqlqawwykadpndftye
rrkesaayipfgegdfyyraaifggtptqvlnitqecfkgilkdkkndieaqwhdeshln
kyfllnkptkilspeycwdyhiglpadiklvkm

    Sequence, based on observed residues (ATOM records): (download) 
    >2vxmC (C:)
klklsdwfnpfkrpevvtmtkwkapvvwegtynravldnyyakqkitvgltvfavgryie
hyleefltsankhfmvghpvifyimvddvsrmplielgplrsfkvfkikpeqdismmrmk
tigehivahiqhevdflfcmdvdqvfqdkfgvetlgesvaqlqawwykadpndftyerrk
esaayipfgegdfyyraaifggtptqvlnitqecfkgilkdkkndieaqwhdeshlnkyf
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  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2vxmD (D:)
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hyleefltsankhfmvghpvifyimvddvsrmplielgplrsfkvfkikpekrwqdismm
rmktigehivahiqhevdflfcmdvdqvfqdkfgvetlgesvaqlqawwykadpndftye
rrkesaayipfgegdfyyraaifggtptqvlnitqecfkgilkdkkndieaqwhdeshln
kyfllnkptkilspeycwdyhiglpadiklvkm

    Sequence, based on observed residues (ATOM records): (download) 
    >2vxmD (D:)
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hyleefltsankhfmvghpvifyimvddvsrmplielgplrsfkvfkikpismmrmktig
ehivahiqhevdflfcmdvdqvfqdkfgvetlgesvaqlqawwykadpndftyerrkesa
ayipfgegdfyyraaifggtptqvlnitqecfkgilkdkkndieaqwhdeshlnkyflln
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