PDB entry 2vwo
View 2vwo on RCSB PDB site
Description: aminopyrrolidine factor xa inhibitor
Class: blood clotting
Keywords: hydrolase, cation, plasma, calcium, zymogen, protease, inhibitor, polymorphism, glycoprotein, gamma-carboxyglutamic acid, blood clotting, coagulation factor, hydroxylation, serine protease, egf-like domain, cleavage on pair of basic residues
Deposited on
2008-06-26, released
2009-07-07
The last revision prior to the SCOPe 2.03 freeze date was dated
2009-07-07, with a file datestamp of
2009-07-02.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.196
AEROSPACI score: 0.56
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: activated factor xa heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot P00742 (71-128)
- engineered mutation (137)
Domains in SCOPe 2.03: d2vwoa_ - Chain 'L':
Compound: factor x light chain
Species: Homo sapiens [TaxId:9606]
Domains in SCOPe 2.03: d2vwol_ - Heterogens: LZG, CA, NA, CL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2vwoA (A:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgeqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
k
Sequence, based on observed residues (ATOM records): (download)
>2vwoA (A:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgeqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktr
- Chain 'L':
Sequence, based on SEQRES records: (download)
>2vwoL (L:)
rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtlerr
Sequence, based on observed residues (ATOM records): (download)
>2vwoL (L:)
lcsldngdcdqfcvvcscargytlakaciptgpypcgkqtler