PDB entry 2vwo

View 2vwo on RCSB PDB site
Description: aminopyrrolidine factor xa inhibitor
Class: blood clotting
Keywords: hydrolase, cation, plasma, calcium, zymogen, protease, inhibitor, polymorphism, glycoprotein, gamma-carboxyglutamic acid, blood clotting, coagulation factor, hydroxylation, serine protease, egf-like domain, cleavage on pair of basic residues
Deposited on 2008-06-26, released 2009-07-07
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-07-07, with a file datestamp of 2009-07-02.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: 0.196
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: activated factor xa heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00742 (71-128)
      • engineered mutation (137)
    Domains in SCOPe 2.01: d2vwoa_
  • Chain 'L':
    Compound: factor x light chain
    Species: Homo sapiens [TaxId:9606]
    Domains in SCOPe 2.01: d2vwol_
  • Heterogens: LZG, CA, NA, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2vwoA (A:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
    tqktgivsgfgrthekgeqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
    cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
    k
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vwoA (A:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
    tqktgivsgfgrthekgeqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
    cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktr
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >2vwoL (L:)
    rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtlerr
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vwoL (L:)
    lcsldngdcdqfcvvcscargytlakaciptgpypcgkqtler