PDB entry 2vwi

View 2vwi on RCSB PDB site
Description: Structure of the OSR1 kinase, a hypertension drug target
Class: transferase
Keywords: kinase, ste kinase, hypertension, transferase
Deposited on 2008-06-25, released 2008-07-08
The last revision prior to the SCOPe 2.05 freeze date was dated 2013-04-17, with a file datestamp of 2013-04-12.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.253
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase osr1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2vwia_
  • Chain 'B':
    Compound: serine/threonine-protein kinase osr1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2vwib_
  • Chain 'C':
    Compound: serine/threonine-protein kinase osr1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2vwic_
  • Chain 'D':
    Compound: serine/threonine-protein kinase osr1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d2vwid_
  • Heterogens: AU, ANP, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vwiA (A:)
msedssalpwsinrddyelqevigsgatavvqaaycapkkekvaikrinlekcqtsmdel
lkeiqamsqchhpnivsyytsfvvkdelwlvmkllsggsvldiikhivakgehksgvlde
stiatilrevlegleylhkngqihrdvkagnillgedgsvqiadfgvsaflatggditrn
kvrktfvgtpcwmapevmeqvrgydfkadiwsfgitaielatgaapyhkyppmkvlmltl
qndppsletgvqdkemlkkygksfrkmislclqkdpekrptaaellrhkffqkaknkefl
qek

    Sequence, based on observed residues (ATOM records): (download) 
    >2vwiA (A:)
nrddyelqevigtavvqaaycekvaikrinamsqchhpnivsyytsfvvkdelwlvmkll
sggsvldiikhivakgehksgvldestiatilrevlegleylhkngqihrdvkagnillg
edgsvqiadfgvsaflagtpcwmapevmeqvrgydfkadiwsfgitaielatgaapyhky
ppmkvlmltlqndppsletemlkkygksfrkmislclqkdpekrptaaellrhkffq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vwiB (B:)
msedssalpwsinrddyelqevigsgatavvqaaycapkkekvaikrinlekcqtsmdel
lkeiqamsqchhpnivsyytsfvvkdelwlvmkllsggsvldiikhivakgehksgvlde
stiatilrevlegleylhkngqihrdvkagnillgedgsvqiadfgvsaflatggditrn
kvrktfvgtpcwmapevmeqvrgydfkadiwsfgitaielatgaapyhkyppmkvlmltl
qndppsletgvqdkemlkkygksfrkmislclqkdpekrptaaellrhkffqkaknkefl
qek

    Sequence, based on observed residues (ATOM records): (download) 
    >2vwiB (B:)
pwsinrddyelqevigsavvqaaycapkkekvaikrinlekcqtsmdellkeiqamsqch
hpnivsyytsfvvkdelwlvmkllsggsvldiikhivakgehksgvldestiatilrevl
egleylhkngqihrdvkagnillgedgsvqiadfgvsaflatggdtpcwmapevmeqvrg
ydfkadiwsfgitaielatgaapyhkyppmkvlmltlqndppsletgmlkkygksfrkmi
slclqkdpekrptaaellrhkffq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >2vwiC (C:)
msedssalpwsinrddyelqevigsgatavvqaaycapkkekvaikrinlekcqtsmdel
lkeiqamsqchhpnivsyytsfvvkdelwlvmkllsggsvldiikhivakgehksgvlde
stiatilrevlegleylhkngqihrdvkagnillgedgsvqiadfgvsaflatggditrn
kvrktfvgtpcwmapevmeqvrgydfkadiwsfgitaielatgaapyhkyppmkvlmltl
qndppsletgvqdkemlkkygksfrkmislclqkdpekrptaaellrhkffqkaknkefl
qek

    Sequence, based on observed residues (ATOM records): (download) 
    >2vwiC (C:)
pwsinrddyelqevigsgatavvqaaycapkkekvaikrinlekcqtsmdellkeiqams
qchhpnivsyytsfvvkdelwlvmkllsggsvldiikhivakgehksgvldestiatilr
evlegleylhkngqihrdvkagnillgedgsvqiadfgvsaflatggditrnkvgtpcwm
apevmeqvrgydfkadiwsfgitaielatgaapyhkyppmkvlmltlqndppsletkkyg
ksfrkmislclqkdpekrptaaellrhkffq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >2vwiD (D:)
msedssalpwsinrddyelqevigsgatavvqaaycapkkekvaikrinlekcqtsmdel
lkeiqamsqchhpnivsyytsfvvkdelwlvmkllsggsvldiikhivakgehksgvlde
stiatilrevlegleylhkngqihrdvkagnillgedgsvqiadfgvsaflatggditrn
kvrktfvgtpcwmapevmeqvrgydfkadiwsfgitaielatgaapyhkyppmkvlmltl
qndppsletgvqdkemlkkygksfrkmislclqkdpekrptaaellrhkffqkaknkefl
qek

    Sequence, based on observed residues (ATOM records): (download) 
    >2vwiD (D:)
salpwsinrddyelqevigsgatavvqaaycapkkekvaikrinlekcqtsmdellkeiq
amsqchhpnivsyytsfvvkdelwlvmkllsggsvldiikhivakgehksgvldestiat
ilrevlegleylhkngqihrdvkagnillgedgsvqiadfgvsaflatggtfvgtpcwma
pevmeqvrgydfkadiwsfgitaielatgaapyhkyppmkvlmltlqndppsletgvqdk
emlkkygksfrkmislclqkdpekrptaaellrhkffqkaknke