PDB entry 2vvc

View 2vvc on RCSB PDB site
Description: aminopyrrolidine factor xa inhibitor
Class: hydrolase
Keywords: hydrolase, zymogen, protease, glycoprotein, gamma-carboxyglutamic acid, blood clotting, coagulation factor, hydroxylation, serine protease, egf-like domain
Deposited on 2008-06-05, released 2009-07-07
The last revision prior to the SCOPe 2.01 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.203
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: activated factor xa heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00742 (0-End)
      • engineered mutation (137)
    Domains in SCOPe 2.01: d2vvca_
  • Chain 'B':
    Compound: activated factor xa heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00742 (0-End)
      • engineered mutation (137)
    Domains in SCOPe 2.01: d2vvcb_
  • Chain 'K':
    Compound: factor x light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2vvck_
  • Chain 'L':
    Compound: factor x light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d2vvcl_
  • Heterogens: LZF, CA, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2vvcA (A:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
    tqktgivsgfgrthekgeqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
    cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
    k
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vvcA (A:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
    tqktgivsgfgrthekgeqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
    cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmk
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >2vvcB (B:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
    qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
    tqktgivsgfgrthekgeqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
    cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
    k
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vvcB (B:)
    ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgggeav
    hevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlmtqktgivs
    gfgrthekgeqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqedacqgdsggp
    hvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmk
    

  • Chain 'K':
    Sequence, based on SEQRES records: (download)
    >2vvcK (K:)
    rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtlerr
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vvcK (K:)
    rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtler
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >2vvcL (L:)
    rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtlerr
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vvcL (L:)
    klcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtle