PDB entry 2vts
View 2vts on RCSB PDB site
Description: identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h-pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design.
Class: transferase
Keywords: transferase, mitosis, cell cycle, serine/threonine protein kinase
Deposited on
2008-05-15, released
2008-08-05
The last revision prior to the SCOPe 2.06 freeze date was dated
2010-11-03, with a file datestamp of
2010-10-29.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.2125
AEROSPACI score: 0.43
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Cell division protein kinase 2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d2vtsa_ - Heterogens: LZC, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2vtsA (A:)
menfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkelnh
pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
Sequence, based on observed residues (ATOM records): (download)
>2vtsA (A:)
menfqkvekigegtygvvykarnkltgevvalkkirpstaireisllkelnhpnivklld
vihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchshrvlhrdl
kpqnllintegaikladfglarafhevvtlwyrapeillgckyystavdiwslgcifaem
vtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkwarqdfskvvppld
edgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl