SCOPe 2.08: Structural Classification of Proteins

PDB entry 2vr4

View 2vr4 on RCSB PDB site
Description: transition-state mimicry in mannoside hydrolysis: characterisation of twenty six inhibitors and insight into binding from linear free energy relationships and 3-d structure
Class: hydrolase
Keywords: linear free energy relationship, hydrolase, transition state mimic, mannosidase, glycoside hydrolase
Deposited on 2008-03-25, released 2008-04-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.179
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: beta-mannosidase
Species: BACTEROIDES THETAIOTAOMICRON [TaxId:226186]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8AAK6 (Start-838)
- PDB 2VR4
Domains in SCOPe 2.08: d2vr4a1, d2vr4a2, d2vr4a3, d2vr4a4, d2vr4a5
Chain 'B':
Compound: beta-mannosidase
Species: BACTEROIDES THETAIOTAOMICRON [TaxId:226186]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8AAK6 (Start-838)
- PDB 2VR4 (839-End)
Domains in SCOPe 2.08: d2vr4b1, d2vr4b2, d2vr4b3, d2vr4b4, d2vr4b5, d2vr4b6
Heterogens: 17B, EDO, BR, CL, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>2vr4A (A:)
qgndtsevmlldtgwefsqsgtekwmpatvpgtvhqdlishellpnpfygmnekkiqwve
nedweyrtsfivseeqlnrdgiqlifegldtyadvylngslllkadnmfvgytlpvksvl
rkgenhlyiyfhspirqtlpqyasngfnypadndhhekhlsvfsrkapysygwdwgirmv
tsgvwrpvtlrfydiatisdyyvrqlsltdenarlsnelivnqivpqkipaevrvnvsln
gttvtevkqqvtlqpginhitlpaevtnpvrwmpngwgtptlydfsaqiacgdrivaeqs
hriglrtirvvnekdkdgesfyfevngipmfakganyipqdallpnvtteryqtlfrdmk
eanmnmvriwgggtyennlfydladengilvwqdfmfactpypsdptflkrveaeavyni
rrlrnhaslamwcgnneilealkywgfekkftpevyqglmhgydklfrellpstvkefds
drfyvhsspylanwgrpeswgtgdshnwgvwygkkpfesldtdlprfmsefgfqsfpemk
tiaafaapedyqiesevmnahqkssignslirtymerdyiipesfedfvyvglvlqgqgm
rhgleahrrnrpycmgtlywqlndswpvvswssidyygnwkalhyqakrafapvlinpiq
qndslsvylisdrldtmeqmtlemkvvdfdgktlgkkiqvhslevpantskcvyrakldg
wltpedcrrsflklilkdksghqvaesvhffrktkdlqlpptsvsyqmkqtdgkceltlf
ssmlakdifietplqgarysdnffdllpgerkkviitsprikkgeelpvnikhiretyke
hhhhhh

Sequence, based on observed residues (ATOM records): (download)

>2vr4A (A:)
ndtsevmlldtgwefsqsgtekwmpatvpgtvhqdlishellpnpfygmnekkiqwvene
dweyrtsfivseeqlnrdgiqlifegldtyadvylngslllkadnmfvgytlpvksvlrk
genhlyiyfhspirqtlpqyasngfnypadndhhekhlsvfsrkapysygwdwgirmvts
gvwrpvtlrfydiatisdyyvrqlsltdenarlsnelivnqivpqkipaevrvnvslngt
tvtevkqqvtlqpginhitlpaevtnpvrwmpngwgtptlydfsaqiacgdrivaeqshr
iglrtirvvnekdkdgesfyfevngipmfakganyipqdallpnvtteryqtlfrdmkea
nmnmvriwgggtyennlfydladengilvwqdfmfactpypsdptflkrveaeavynirr
lrnhaslamwcgnneilealkywgfekkftpevyqglmhgydklfrellpstvkefdsdr
fyvhsspylanwgrpeswgtgdshnwgvwygkkpfesldtdlprfmsefgfqsfpemkti
aafaapedyqiesevmnahqkssignslirtymerdyiipesfedfvyvglvlqgqgmrh
gleahrrnrpycmgtlywqlndswpvvswssidyygnwkalhyqakrafapvlinpiqqn
dslsvylisdrldtmeqmtlemkvvdfdgktlgkkiqvhslevpantskcvyrakldgwl
tpedcrrsflklilkdksghqvaesvhffrktkdlqlpptsvsyqmkqtdgkceltlfss
mlakdifietplqgarysdnffdllpgerkkviitsprikkgelpvnikhiretyk

Chain 'B':
Sequence, based on SEQRES records: (download)

>2vr4B (B:)
qgndtsevmlldtgwefsqsgtekwmpatvpgtvhqdlishellpnpfygmnekkiqwve
nedweyrtsfivseeqlnrdgiqlifegldtyadvylngslllkadnmfvgytlpvksvl
rkgenhlyiyfhspirqtlpqyasngfnypadndhhekhlsvfsrkapysygwdwgirmv
tsgvwrpvtlrfydiatisdyyvrqlsltdenarlsnelivnqivpqkipaevrvnvsln
gttvtevkqqvtlqpginhitlpaevtnpvrwmpngwgtptlydfsaqiacgdrivaeqs
hriglrtirvvnekdkdgesfyfevngipmfakganyipqdallpnvtteryqtlfrdmk
eanmnmvriwgggtyennlfydladengilvwqdfmfactpypsdptflkrveaeavyni
rrlrnhaslamwcgnneilealkywgfekkftpevyqglmhgydklfrellpstvkefds
drfyvhsspylanwgrpeswgtgdshnwgvwygkkpfesldtdlprfmsefgfqsfpemk
tiaafaapedyqiesevmnahqkssignslirtymerdyiipesfedfvyvglvlqgqgm
rhgleahrrnrpycmgtlywqlndswpvvswssidyygnwkalhyqakrafapvlinpiq
qndslsvylisdrldtmeqmtlemkvvdfdgktlgkkiqvhslevpantskcvyrakldg
wltpedcrrsflklilkdksghqvaesvhffrktkdlqlpptsvsyqmkqtdgkceltlf
ssmlakdifietplqgarysdnffdllpgerkkviitsprikkgeelpvnikhiretyke
hhhhhh

Sequence, based on observed residues (ATOM records): (download)

>2vr4B (B:)
gndtsevmlldtgwefsqsgtekwmpatvpgtvhqdlishellpnpfygmnekkiqwven
edweyrtsfivseeqlnrdgiqlifegldtyadvylngslllkadnmfvgytlpvksvlr
kgenhlyiyfhspirqtlpqyasngfnypadndhhekhlsvfsrkapysygwdwgirmvt
sgvwrpvtlrfydiatisdyyvrqlsltdenarlsnelivnqivpqkipaevrvnvslng
ttvtevkqqvtlqpginhitlpaevtnpvrwmpngwgtptlydfsaqiacgdrivaeqsh
riglrtirvvnekdkdgesfyfevngipmfakganyipqdallpnvtteryqtlfrdmke
anmnmvriwgggtyennlfydladengilvwqdfmfactpypsdptflkrveaeavynir
rlrnhaslamwcgnneilealkywgfekkftpevyqglmhgydklfrellpstvkefdsd
rfyvhsspylanwgrpeswgtgdshnwgvwygkkpfesldtdlprfmsefgfqsfpemkt
iaafaapedyqiesevmnahqkssignslirtymerdyiipesfedfvyvglvlqgqgmr
hgleahrrnrpycmgtlywqlndswpvvswssidyygnwkalhyqakrafapvlinpiqq
ndslsvylisdrldtmeqmtlemkvvdfdgktlgkkiqvhslevpantskcvyrakldgw
ltpedcrrsflklilkdksghqvaesvhffrktkdlqlpptsvsyqmkqtdgkceltlfs
smlakdifietplqgarysdnffdllpgerkkviitsprikkgeelpvnikhiretykeh
h