PDB entry 2vqo

View 2vqo on RCSB PDB site
Description: structure of hdac4 catalytic domain with a gain-of-function muation bound to a trifluoromethylketone inhbitor
Deposited on 2008-03-18, released 2008-07-08
The last revision was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.212
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Histone deacetylase 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VQO
      • engineered mutation (55)
      • engineered mutation (331)
    • Uniprot P56524
  • Chain 'B':
    Compound: Histone deacetylase 4
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VQO
      • engineered mutation (55)
      • engineered mutation (331)
    • Uniprot P56524
  • Heterogens: SO4, K, TFG, ZN, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2vqoA (A:)
gamtkprfttglvydtlmlkhqctagsssshpehagriqsiwsrlqetglrgkceairgr
katleelqtvhseahtllygtnplnrqkldskkllgslasvfvrlpcggvgvdsdtiwne
vhsagaarlavgcvvelvfkvatgelkngfavvrppghhaeestpmgfcyfnsvavaakl
lqqrlsvskilivdwdvhhgngtqqafysdpsvlymslhryddgnffpgsgapdevgtgp
gvgfnvnmaftggldppmgdaeylaafrtvvmpiasefapdvvlvssgfdaveghptplg
gynlsarcfgyltkqlmglaggrivlaleggydltaicdaseacvsallgneldplpekv
lqqrpnanavrsmekvmeihskywrclqrttstagrslieaqtceneeaetvt

    Sequence, based on observed residues (ATOM records):
    >2vqoA (A:)
rfttglvydtlmlkhqagriqsiwsrlqetglrgkceairgrkatleelqtvhseahtll
ygtnplvdsdtiwnevhsagaarlavgcvvelvfkvatgelkngfavvrppghhaeestp
mgfcyfnsvavaakllqqrlsvskilivdwdvhhgngtqqafysdpsvlymslhryddgn
ffpgsgapdevgtgpgvgfnvnmaftggldppmgdaeylaafrtvvmpiasefapdvvlv
ssgfdaveghptplggynlsarcfgyltkqlmglaggrivlaleggydltaicdaseacv
sallgneldplpekvlqqrpnanavrsmekvmeihskywrclqrttstagrslieaqtce

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2vqoB (B:)
gamtkprfttglvydtlmlkhqctagsssshpehagriqsiwsrlqetglrgkceairgr
katleelqtvhseahtllygtnplnrqkldskkllgslasvfvrlpcggvgvdsdtiwne
vhsagaarlavgcvvelvfkvatgelkngfavvrppghhaeestpmgfcyfnsvavaakl
lqqrlsvskilivdwdvhhgngtqqafysdpsvlymslhryddgnffpgsgapdevgtgp
gvgfnvnmaftggldppmgdaeylaafrtvvmpiasefapdvvlvssgfdaveghptplg
gynlsarcfgyltkqlmglaggrivlaleggydltaicdaseacvsallgneldplpekv
lqqrpnanavrsmekvmeihskywrclqrttstagrslieaqtceneeaetvt

    Sequence, based on observed residues (ATOM records):
    >2vqoB (B:)
rfttglvydtlmlkhagriqsiwsrlqetglrgkceairgrkatleelqtvhseahtlly
gtnpldsdtiwnevhsagaarlavgcvvelvfkvatgelkngfavvrppghhaeestpmg
fcyfnsvavaakllqqrlsvskilivdwdvhhgngtqqafysdpsvlymslhryddgnff
pgsgapdevgtgpgvgfnvnmaftggldppmgdaeylaafrtvvmpiasefapdvvlvss
gfdaveghptplggynlsarcfgyltkqlmglaggrivlaleggydltaicdaseacvsa
llgneldplpekvlqqrpnanavrsmekvmeihskywrclqrttstagrslieaqtce