PDB entry 2vo6

View 2vo6 on RCSB PDB site
Description: structure of pka-pkb chimera complexed with 4-(4-chlorobenzyl)-1-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)piperidin-4-ylamine
Class: transferase
Keywords: transferase, lipoprotein, ATP-binding, phosphoprotein, serine/threonine-protein kinase, nucleotide-binding, protein kinase inhibitor, camp, kinase, nucleus, myristate, cytoplasm
Deposited on 2008-02-08, released 2008-04-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 1.97 Å
R-factor: 0.175
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-dependent protein kinase, alpha-catalytic subunit
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00517 (Start-350)
      • engineered mutation (104)
      • engineered mutation (123)
      • engineered mutation (173)
      • engineered mutation (181)
    Domains in SCOPe 2.06: d2vo6a_
  • Chain 'I':
    Compound: cAMP-dependent protein kinase inhibitor alpha
    Species: HOMO SAPIENS, synthetic [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CL, M05, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >2vo6A (A:)
    mgnaaaakkgseqesvkeflakakedflkkwenpaqntahldqferiktlgtgsfgrvml
    vkhmetgnhyamkildkqkvvklkqiehtlnekrilqavnfpfltklefsfkdnsnlymv
    meyapggemfshlrrigrfsepharfyaaqivltfeylhsldliyrdlkpenlmidqqgy
    ikvtdfgfakrvkgrtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppff
    adqpiqiyekivsgkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfat
    tdwiaiyqrkveapfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vo6A (A:)
    esvkeflakakedflkkwenpaqntahldqferiktlgtgsfgrvmlvkhmetgnhyamk
    ildkqkvvklkqiehtlnekrilqavnfpfltklefsfkdnsnlymvmeyapggemfshl
    rrigrfsepharfyaaqivltfeylhsldliyrdlkpenlmidqqgyikvtdfgfakrvk
    grtwtlcgtpeylapeiilskgynkavdwwalgvliyemaagyppffadqpiqiyekivs
    gkvrfpshfssdlkdllrnllqvdltkrfgnlkngvndiknhkwfattdwiaiyqrkvea
    pfipkfkgpgdtsnfddyeeeeirvsinekcgkefsef
    

  • Chain 'I':
    No sequence available.