PDB entry 2vn0

View 2vn0 on RCSB PDB site
Description: cyp2c8dh complexed with troglitazone
Class: oxidoreductase
Keywords: oxidoreductase, electron transport, endoplasmic reticulum, metal-binding, palmitic acid, human p450 2c8, troglitazone, polymorphism, monooxygenase, iron, heme, cyp2c8, membrane, microsome, monooxygenases, inhibitor complex
Deposited on 2008-01-30, released 2008-04-29
The last revision prior to the SCOPe 2.03 freeze date was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: 0.218
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome P450 2C8
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VN0 (472-End)
    • Uniprot P10632 (9-471)
    Domains in SCOPe 2.03: d2vn0a_
  • Heterogens: HEM, TDZ, PLM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vn0A (A:)
makktsskgklppgptplpiignmlqidvkdicksftnfskvygpvftvyfgmnpivvfh
gyeavkealidngeefsgrgnspisqritkglgiissngkrwkeirrfslttlrnfgmgk
rsiedrvqeeahclveelrktkaspcdptfilgcapcnvicsvvfqkrfdykdqnfltlm
krfnenfrilnspwiqvcnnfpllidcfpgthnkvlknvaltrsyirekvkehqasldvn
nprdfidcflikmeqekdnqksefnienlvgtvadlfvagtettsttlryglllllkhpe
vtakvqeeidhvigrhrspcmqdrshmpytdavvheiqrysdlvptgvphavttdtkfrn
ylipkgttimalltsvlhddkefpnpnifdpghfldkngnfkksdyfmpfsagkricage
glarmelflflttilqnfnlksvddlknlnttavtkgivslppsyqicfipvhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >2vn0A (A:)
klppgptplpiignmlqidvkdicksftnfskvygpvftvyfgmnpivvfhgyeavkeal
idngeefsgrgnspisqritkglgiissngkrwkeirrfslttlrnfgmgkrsiedrvqe
eahclveelrktkaspcdptfilgcapcnvicsvvfqkrfdykdqnfltlmkrfnenfri
lnspwiqvcnnfpllidcfpgthnkvlknvaltrsyirekvkehqasldvnnprdfidcf
likmeqekdnqksefnienlvgtvadlfvagtettsttlryglllllkhpevtakvqeei
dhvigrhrspcmqdrshmpytdavvheiqrysdlvptgvphavttdtkfrnylipkgtti
malltsvlhddkefpnpnifdpghfldkngnfkksdyfmpfsagkricageglarmelfl
flttilqnfnlksvddlknlnttavtkgivslppsyqicfipvh