PDB entry 2vlr

View 2vlr on RCSB PDB site
Description: the structural dynamics and energetics of an immunodominant T-cell receptor are programmed by its vbeta domain
Class: immune system
Keywords: immune system, glycoprotein, transmembrane, immune system-receptor-complex, immunoglobulin domain, host-virus interaction, pyrrolidone carboxylic acid, immune response, immunodominance, disease mutation, membrane, secreted, receptor, glycation, tcr, flu, MHC, MHC I, T-cell, complex
Deposited on 2008-01-15, released 2008-01-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-31.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.222
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2vlra1, d2vlra2
  • Chain 'B':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VLR (0-0)
    • Uniprot P61769 (1-99)
    Domains in SCOPe 2.06: d2vlrb2, d2vlrb3
  • Chain 'C':
    Compound: flu matrix peptide
    Species: UNIDENTIFIED INFLUENZA VIRUS, synthetic [TaxId:11309]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VLR (0-8)
  • Chain 'D':
    Compound: jm22 tcr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VLR
  • Chain 'E':
    Compound: jm22 tcr beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VLR (Start-243)
    Domains in SCOPe 2.06: d2vlre1, d2vlre2
  • Chain 'F':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d2vlrf1, d2vlrf2
  • Chain 'G':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VLR (0-0)
    • Uniprot P61769 (1-99)
    Domains in SCOPe 2.06: d2vlrg2, d2vlrg3
  • Chain 'H':
    Compound: flu matrix peptide
    Species: UNIDENTIFIED INFLUENZA VIRUS, synthetic [TaxId:11309]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VLR (0-8)
  • Chain 'I':
    Compound: jm22 tcr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VLR
  • Chain 'J':
    Compound: jm22 tcr beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VLR (Start-243)
    Domains in SCOPe 2.06: d2vlrj1, d2vlrj2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2vlrA (A:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwep
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2vlrB (B:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.

  • Chain 'E':
    Sequence, based on SEQRES records: (download)
    >2vlrE (E:)
    mvdggitqspkylfrkegqnvtlsceqnlnhdamywyrqdpgqglrliyysqivndfqkg
    diaegysvsrekkesfpltvtsaqknptafylcasssrasyeqyfgpgtrltvtedlknv
    fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplkeq
    palndsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
    grad
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vlrE (E:)
    gitqspkylfrkegqnvtlsceqnlnhdamywyrqdpgqglrliyysqivndfqkgdiae
    gysvsrekkesfpltvtsaqknptafylcasssrasyeqyfgpgtrltvtedlknvfppe
    vavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplkeqpaln
    dsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad
    

  • Chain 'F':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2vlrF (F:)
    gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
    dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
    kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
    rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
    fqkwaavvvpsgqeqrytchvqheglpkpltlrwep
    

  • Chain 'G':
    Sequence; same for both SEQRES and ATOM records: (download)
    >2vlrG (G:)
    miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
    wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm
    

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    No sequence available.

  • Chain 'J':
    Sequence, based on SEQRES records: (download)
    >2vlrJ (J:)
    mvdggitqspkylfrkegqnvtlsceqnlnhdamywyrqdpgqglrliyysqivndfqkg
    diaegysvsrekkesfpltvtsaqknptafylcasssrasyeqyfgpgtrltvtedlknv
    fppevavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplkeq
    palndsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeaw
    grad
    

    Sequence, based on observed residues (ATOM records): (download)
    >2vlrJ (J:)
    gitqspkylfrkegqnvtlsceqnlnhdamywyrqdpgqglrliyysqivndfqkgdiae
    gysvsrekkesfpltvtsaqknptafylcasssrasyeqyfgpgtrltvtedlknvfppe
    vavfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvstdpqplkeqpaln
    dsryslssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad