PDB entry 2vhx

View 2vhx on RCSB PDB site
Description: crystal structure of the ternary complex of l-alanine dehydrogenase from mycobacterium tuberculosis with nad+ and pyruvate
Deposited on 2007-11-26, released 2008-03-11
The last revision was dated 2009-02-24, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.174
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: alanine dehydrogenase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30234 (0-370)
    • PDB 2VHX
  • Chain 'B':
    Compound: alanine dehydrogenase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30234 (0-370)
    • PDB 2VHX
  • Chain 'C':
    Compound: alanine dehydrogenase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30234 (0-End)
    • PDB 2VHX
  • Chain 'D':
    Compound: alanine dehydrogenase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30234 (0-End)
    • PDB 2VHX
  • Chain 'E':
    Compound: alanine dehydrogenase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30234 (0-370)
    • PDB 2VHX (371-End)
  • Chain 'F':
    Compound: alanine dehydrogenase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30234 (0-370)
    • PDB 2VHX (371-End)
  • Heterogens: MG, PYR, NAD, HOH

PDB Chain Sequences:
This PDB entry is not classified in SCOPe 2.08, so the chain sequences below are not included in the ASTRAL sequence sets.

  • Chain 'A':
    Sequence, based on SEQRES records:
    >2vhxA (A:)
mrvgiptetknnefrvaitpagvaeltrrghevliqagagegsaitdadfkaagaqlvgt
adqvwadadlllkvkepiaaeygrlrhgqilftflhlaasractdalldsgttsiayetv
qtadgalpllapmsevagrlaaqvgayhlmrtqggrgvlmggvpgvepadvvvigagtag
ynaariangmgatvtvldinidklrqldaefcgrihtryssayelegavkradlvigavl
vpgakapklvsnslvahmkpgavlvdiaidqggcfegsrpttydhptfavhdtlfycvan
mpasvpktstyaltnatmpyvleladhgwraacrsnpalakglsthegallservatdlg
vpftepasvlahhhhhh

    Sequence, based on observed residues (ATOM records):
    >2vhxA (A:)
mrvgiptetknnefrvaitpagvaeltrrghevliqagagegsaitdadfkaagaqlvgt
adqvwadadlllkvkepiaaeygrlrhgqilftflhlaasractdalldsgttsiayetv
qtadgalpllapmsevagrlaaqvgayhlmrtqggrgvlmggvpgvepadvvvigagtag
ynaariangmgatvtvldinidklrqldaefcgrihtryssayelegavkradlvigavl
vkapklvsnslvahmkpgavlvdiaidqggcfegsrpttydhptfavhdtlfycvanmpa
svpktstyaltnatmpyvleladhgwraacrsnpalakglsthegallservatdlgvpf
tepasvla

  • Chain 'B':
    Sequence, based on SEQRES records:
    >2vhxB (B:)
mrvgiptetknnefrvaitpagvaeltrrghevliqagagegsaitdadfkaagaqlvgt
adqvwadadlllkvkepiaaeygrlrhgqilftflhlaasractdalldsgttsiayetv
qtadgalpllapmsevagrlaaqvgayhlmrtqggrgvlmggvpgvepadvvvigagtag
ynaariangmgatvtvldinidklrqldaefcgrihtryssayelegavkradlvigavl
vpgakapklvsnslvahmkpgavlvdiaidqggcfegsrpttydhptfavhdtlfycvan
mpasvpktstyaltnatmpyvleladhgwraacrsnpalakglsthegallservatdlg
vpftepasvlahhhhhh

    Sequence, based on observed residues (ATOM records):
    >2vhxB (B:)
mrvgiptetknnefrvaitpagvaeltrrghevliqagagegsaitdadfkaagaqlvgt
adqvwadadlllkvkepiaaeygrlrhgqilftflhlaasractdalldsgttsiayetv
qtadgalpllapmsevagrlaaqvgayhlmrtqggrgvlmggvpgvepadvvvigagtag
ynaariangmgatvtvldinidklrqldaefcgrihtryssayelegavkradlvigavl
akapklvsnslvahmkpgavlvdiaidqggcfegsrpttydhptfavhdtlfycvanmpa
svpktstyaltnatmpyvleladhgwraacrsnpalakglsthegallservatdlgvpf
tepasvla

  • Chain 'C':
    Sequence, based on SEQRES records:
    >2vhxC (C:)
mrvgiptetknnefrvaitpagvaeltrrghevliqagagegsaitdadfkaagaqlvgt
adqvwadadlllkvkepiaaeygrlrhgqilftflhlaasractdalldsgttsiayetv
qtadgalpllapmsevagrlaaqvgayhlmrtqggrgvlmggvpgvepadvvvigagtag
ynaariangmgatvtvldinidklrqldaefcgrihtryssayelegavkradlvigavl
vpgakapklvsnslvahmkpgavlvdiaidqggcfegsrpttydhptfavhdtlfycvan
mpasvpktstyaltnatmpyvleladhgwraacrsnpalakglsthegallservatdlg
vpftepasvlahhhhhh

    Sequence, based on observed residues (ATOM records):
    >2vhxC (C:)
mrvgiptetknnefrvaitpagvaeltrrghevliqagagegsaitdadfkaagaqlvgt
adqvwadadlllkvkepiaaeygrlrhgqilftflhlaasractdalldsgttsiayetv
qtadgalpllapmsevagrlaaqvgayhlmrtqggrgvlmggvpgvepadvvvigagtag
ynaariangmgatvtvldinidklrqldaefcgrihtryssayelegavkradlvigavl
apklvsnslvahmkpgavlvdiaidqggcfegsrpttydhptfavhdtlfycvanmpasv
pktstyaltnatmpyvleladhgwraacrsnpalakglsthegallservatdlgvpfte
pasvl

  • Chain 'D':
    Sequence, based on SEQRES records:
    >2vhxD (D:)
mrvgiptetknnefrvaitpagvaeltrrghevliqagagegsaitdadfkaagaqlvgt
adqvwadadlllkvkepiaaeygrlrhgqilftflhlaasractdalldsgttsiayetv
qtadgalpllapmsevagrlaaqvgayhlmrtqggrgvlmggvpgvepadvvvigagtag
ynaariangmgatvtvldinidklrqldaefcgrihtryssayelegavkradlvigavl
vpgakapklvsnslvahmkpgavlvdiaidqggcfegsrpttydhptfavhdtlfycvan
mpasvpktstyaltnatmpyvleladhgwraacrsnpalakglsthegallservatdlg
vpftepasvlahhhhhh

    Sequence, based on observed residues (ATOM records):
    >2vhxD (D:)
mrvgiptetknnefrvaitpagvaeltrrghevliqagagegsaitdadfkaagaqlvgt
adqvwadadlllkvkepiaaeygrlrhgqilftflhlaasractdalldsgttsiayetv
qtadgalpllapmsevagrlaaqvgayhlmrtqggrgvlmggvpgvepadvvvigagtag
ynaariangmgatvtvldinidklrqldaefcgrihtryssayelegavkradlvigavl
akapklvsnslvahmkpgavlvdiaidqggcfegsrpttydhptfavhdtlfycvanmpa
svpktstyaltnatmpyvleladhgwraacrsnpalakglsthegallservatdlgvpf
tepasvl

  • Chain 'E':
    Sequence, based on SEQRES records:
    >2vhxE (E:)
mrvgiptetknnefrvaitpagvaeltrrghevliqagagegsaitdadfkaagaqlvgt
adqvwadadlllkvkepiaaeygrlrhgqilftflhlaasractdalldsgttsiayetv
qtadgalpllapmsevagrlaaqvgayhlmrtqggrgvlmggvpgvepadvvvigagtag
ynaariangmgatvtvldinidklrqldaefcgrihtryssayelegavkradlvigavl
vpgakapklvsnslvahmkpgavlvdiaidqggcfegsrpttydhptfavhdtlfycvan
mpasvpktstyaltnatmpyvleladhgwraacrsnpalakglsthegallservatdlg
vpftepasvlahhhhhh

    Sequence, based on observed residues (ATOM records):
    >2vhxE (E:)
mrvgiptetknnefrvaitpagvaeltrrghevliqagagegsaitdadfkaagaqlvgt
adqvwadadlllkvkepiaaeygrlrhgqilftflhlaasractdalldsgttsiayetv
qtadgalpllapmsevagrlaaqvgayhlmrtqggrgvlmggvpgvepadvvvigagtag
ynaariangmgatvtvldinidklrqldaefcgrihtryssayelegavkradlvigavl
vpgakapklvsnslvahmkpgavlvdiaidqggcfegsrpttydhptfavhdtlfycvan
mpasvpktstyaltnatmpyvleladhgwraacrsnpalakglsthegallservatdlg
vpftepasvlahh

  • Chain 'F':
    Sequence, based on SEQRES records:
    >2vhxF (F:)
mrvgiptetknnefrvaitpagvaeltrrghevliqagagegsaitdadfkaagaqlvgt
adqvwadadlllkvkepiaaeygrlrhgqilftflhlaasractdalldsgttsiayetv
qtadgalpllapmsevagrlaaqvgayhlmrtqggrgvlmggvpgvepadvvvigagtag
ynaariangmgatvtvldinidklrqldaefcgrihtryssayelegavkradlvigavl
vpgakapklvsnslvahmkpgavlvdiaidqggcfegsrpttydhptfavhdtlfycvan
mpasvpktstyaltnatmpyvleladhgwraacrsnpalakglsthegallservatdlg
vpftepasvlahhhhhh

    Sequence, based on observed residues (ATOM records):
    >2vhxF (F:)
mrvgiptetknnefrvaitpagvaeltrrghevliqagagegsaitdadfkaagaqlvgt
adqvwadadlllkvkepiaaeygrlrhgqilftflhlaasractdalldsgttsiayetv
qtadgalpllapmsevagrlaaqvgayhlmrtqggrgvlmggvpgvepadvvvigagtag
ynaariangmgatvtvldinidklrqldaefcgrihtryssayelegavkradlvigavl
vpgakapklvsnslvahmkpgavlvdiaidqggcfegsrpttydhptfavhdtlfycvan
mpasvpktstyaltnatmpyvleladhgwraacrsnpalakglsthegallservatdlg
vpftepasvlahh