PDB entry 2vh5

View 2vh5 on RCSB PDB site
Description: CRYSTAL STRUCTURE OF HRAS(G12V) - ANTI-RAS FV (disulfide free mutant) COMPLEX
Class: immune system
Keywords: immunoglobulin domain, signaling protein/immune system, methylation, prenylation, lipoprotein, GTP-binding, signal transduction, nucleotide- binding, disease mutation, nucleotide-binding, immune system, membrane, oncogene, antibody, palmitate, intrabody, proto-oncogene, cancer therapy, golgi apparatus
Deposited on 2007-11-19, released 2008-01-22
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-01-24, with a file datestamp of 2018-01-19.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'H':
    Compound: anti-ras fv heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VH5 (0-113)
    Domains in SCOPe 2.08: d2vh5h_
  • Chain 'L':
    Compound: anti-ras fv light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 2VH5 (0-103)
    Domains in SCOPe 2.08: d2vh5l_
  • Chain 'R':
    Compound: gtpase hras
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01112 (0-165)
      • engineered mutation (11)
    Domains in SCOPe 2.08: d2vh5r_
  • Heterogens: ZN, GTP, MG, HOH

PDB Chain Sequences:

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2vh5H (H:)
evqllesggglvqpggslrlsaaasgftfstfsmnwvrqapgkglewvsyisrtsktiyy
adsvkgrftisrdnskntlylqmnslraedtavyyvargrffdywgqgtlvtvs

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2vh5L (L:)
iqmtqspsslsasvgdrvtitvrasqsissylnwyqqkpgeapklliysasvlqsgvpsr
fsgsgsgtdftltisslqpedfatyyaqqsvmipmtfgqgtkve

  • Chain 'R':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2vh5R (R:)
mteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildtag
qeeysamrdqymrtgegflcvfainntksfedihqyreqikrvkdsddvpmvlvgnkcdl
aartvesrqaqdlarsygipyietsaktrqgvedafytlvreirqh