PDB entry 2vh0
View 2vh0 on RCSB PDB site
Description: structure and property based design of factor xa inhibitors: biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs
Class: hydrolase
Keywords: serine protease, egf-like domain, blood coagulation, polymorphism, glycoprotein, hydroxylation, gamma-carboxyglutamic acid, calcium, zymogen, complex, protease, hydrolase, cleavage on pair of basic residues
Deposited on
2007-11-16, released
2008-11-25
The last revision prior to the SCOPe 2.07 freeze date was dated
2009-02-24, with a file datestamp of
2009-03-01.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.189
AEROSPACI score: 0.55
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: activated factor xa heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d2vh0a_ - Chain 'B':
Compound: activated factor xa light chain
Species: Homo sapiens [TaxId:9606]
Domains in SCOPe 2.07: d2vh0b_ - Heterogens: CA, MG, GSI, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2vh0A (A:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
kshapevitssplk
Sequence, based on observed residues (ATOM records): (download)
>2vh0A (A:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2vh0B (B:)
eemkkghlerecmeetcsyeearevfedsdktnefwnkykdgdqcetspcqnqgkckdgl
geytctclegfegkncelftrklcsldngdcdqfcheeqnsvvcscargytladngkaci
ptgpypcgkqtler
Sequence, based on observed residues (ATOM records): (download)
>2vh0B (B:)
rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtl