PDB entry 2vh0

View 2vh0 on RCSB PDB site
Description: Structure and property based design of factor Xa inhibitors:biaryl pyrrolidin-2-ones incorporating basic heterocyclic motifs
Class: hydrolase
Keywords: serine protease, egf-like domain, blood coagulation, polymorphism, glycoprotein, hydroxylation, gamma-carboxyglutamic acid, calcium, zymogen, complex, protease, hydrolase, cleavage on pair of basic residues
Deposited on 2007-11-16, released 2008-11-25
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-05-08, with a file datestamp of 2019-05-03.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: activated factor xa heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vh0a_
  • Chain 'B':
    Compound: activated factor xa light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d2vh0b_
  • Heterogens: CA, MG, GSI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2vh0A (A:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmktrglpka
kshapevitssplk

    Sequence, based on observed residues (ATOM records): (download) 
    >2vh0A (A:)
ivggqeckdgecpwqallineenegfcggtilsefyiltaahclyqakrfkvrvgdrnte
qeeggeavhevevvikhnrftketydfdiavlrlktpitfrmnvapaclperdwaestlm
tqktgivsgfgrthekgrqstrlkmlevpyvdrnscklsssfiitqnmfcagydtkqeda
cqgdsggphvtrfkdtyfvtgivswgegcarkgkygiytkvtaflkwidrsmkt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >2vh0B (B:)
eemkkghlerecmeetcsyeearevfedsdktnefwnkykdgdqcetspcqnqgkckdgl
geytctclegfegkncelftrklcsldngdcdqfcheeqnsvvcscargytladngkaci
ptgpypcgkqtler

    Sequence, based on observed residues (ATOM records): (download) 
    >2vh0B (B:)
rklcsldngdcdqfcheeqnsvvcscargytladngkaciptgpypcgkqtl